5952-93-2

Basic information

• Product Name: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
• Synonyms: Methyl 1-Methyl-1H-pyrazole-4-carboxylate;Methyl 1-methyl-4-pyrazolecarboxylate;methyl 1-methylpyrazole-4-carboxylate;1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
• CAS NO: 5952-93-2
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.14
• Mol File: 5952-93-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 62.0-62.5 °C
• Boiling Point: 221.6±13.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: -0.01±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(5952-93-2)
• EPA Substance Registry System: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(5952-93-2)

Safety Data

• Hazardous Substances Data: 5952-93-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazole-4-carboxylic acid methyl ester is a chemical compound commonly used as an intermediate in pharmaceutical and agrochemical synthesis. It is a methyl ester derivative of 1-methyl-1H-pyrazole-4-carboxylic acid, which is a nitrogen-based heterocyclic compound. This chemical is a white solid with a molecular formula of C7H8N2O2 and a molecular weight of 152.15 g/mol. It is used in the synthesis of various pharmaceuticals, pesticides, and other organic compounds. The compound is also known to have biological activity and is being studied for its potential applications in medical research.

Upstream product

• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 5952-92-1 1-methyl-1H-pyrazole-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 624-49-7 dimethylfumarate 
• 256658-45-4 C₅H₁₄N₂OSi 
• 64182-19-0 methyl 3-amino-1-methylpyrazole-4-carboxylate 
• 110860-60-1 methyl 5-amino-1-methylpyrazole-4-carboxylate 

Downstream Products

• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 
• 34091-53-7 3,4-diiodo-1-methylpyrazole 
• 34091-52-6 4,5-diiodo-1-methylpyrazole 
• 1610361-24-4 C₂₀H₂₄N₆OS 
• 1412407-44-3 C₁₉H₂₄N₆OS 
• 170020-91-4 1-methyl-1H-pyrazole-4-carboxylic acid hydrazide 
• 100784-20-1 halosulfuron methyl 
• 100784-27-8 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide 
• 88398-85-0 Methyl 5-Chloro-1-methylpyrazole-4-carboxylate 
• 109056-69-1 methyl 3,5-dichloro-1-methyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

We report on the development of a continuous flow process for the palladium catalysed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of carbon monoxide into solution at elevated pressures. The low volume of pressurised gas within the reactor (5.6 mL) offers the potential for an enhanced safety profile compared to batch processes. We also present preliminary results for the use of in situ FTIR to measure solution concentrations of carbon monoxide and demonstrate the use of a second reactor to effect the removal of carbon monoxide from the flow stream.

Process for preparing heterocycles

Process for the preparation of heterocycles by reacting 2-substituted acetals of malondialdehyde with a reactant selected from hydroxylamines and their salts, hydrazines and their salts, formamid, amidines and their salts, guanidines and their salts, aminoguanidines and their salts, nitroguanidine and their salts, O-alkyl-isoureas and their salts, O-cycloalkyl-isoureas and their salts, O-aralkyl-isoureas and their salts, O-aryl-isoureas and their salts, S-alkyl-isothioureas, S-cycloalkyl-isothioureas, S-aralkyl-isothioureas, S-arylisothioureas, S-alkyl-isothiouronium salts, S-cycloalkyl-isothiouronium salts, S-aralkyl-isothiouronium salts, S-aryl-isothiuronium salts, thiourea and urea.