(R)-4-Morpholino-1-(phenylthio)-2-butylamine

Base Information

• Chemical Name: (R)-4-Morpholino-1-(phenylthio)-2-butylamine
• CAS No.: 870812-95-6
• Molecular Formula: C14H22N2OS
• Molecular Weight: 266.407
• Mol file: 870812-95-6.mol

Synonyms:(R)-4-morpholino-1-(phenylthio)butan-2-amine;trans-(E)-Allethrin II;Allethrin II;(1R)-3-(4-morpholinyl)-1-((phenylsulfanyl)methyl)propylamine;Rethrin II;(R)-4-Morpholino-1-(phenylthio)-2-butylamine;

Chemical Property of (R)-4-Morpholino-1-(phenylthio)-2-butylamine

Chemical Property:

• PSA: 63.79000
• LogP: 2.46650
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(R)-4-Morpholino-1-(phenylthio)-2-butylamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-Morpholino-1-(phenylthio)-2-butylamine

There total 1 articles about (R)-4-Morpholino-1-(phenylthio)-2-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylamine (870812-94-5) → (R)-4-morpholino-1-(phenylthio)butan-2-amine (870812-95-6)

Guidance literature:

(1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylamine; With borane-THF; In tetrahydrofuran; methanol; at 55 ℃; for 19h;

With hydrogenchloride; In methanol; for 24h; Heating / reflux;

Reference yield: 87.0%

(R)-4-morpholino-1-(phenylthio)butan-2-amine (870812-95-6) + 4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide (1027345-08-9) → [4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide (1027345-12-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 16h;

DOI:10.1055/s-2008-1067129

Reference yield: 61.0%

(R)-4-morpholino-1-(phenylthio)butan-2-amine (870812-95-6) + C26H29F4N3O7S2 → C40H50F3N5O8S3

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.bmcl.2014.05.036

upstream raw materials:

(1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylamine

Downstream raw materials:

[4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide

(R)-5-(4-chlorophenyl)-1,2-dimethyl-4-(3-(4-(4-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid