1027345-08-9

Basic information

• Product Name: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide
• Synonyms: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide;4-fluoro-3-(trifluoroMethane)sulfonylbenzene-1-sulfonaMide;BenzenesulfonaMide, 4-fluoro-3-[(trifluoroMethyl)sulfonyl]-;EOS-62146
• CAS NO: 1027345-08-9
• Molecular Formula: C₇H₅F₄NO₄S₂
• Molecular Weight: 307.2425128
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1027345-08-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 436.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.699
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, DMSO, Ethanol, Methanol
• PKA: 9.30±0.60(Predicted)
• CAS DataBase Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)
• EPA Substance Registry System: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)

Safety Data

• Hazardous Substances Data: 1027345-08-9(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

An intermediate in the production of anticancer drugs

Upstream product

• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 52200-99-4 2-fluoro-benzenesulfonyl fluoride 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 88-74-4 2-nitro-aniline 
• 1978-16-1 1-fluoro-2-(trifluoromethylsulfanyl)benzene 
• 2557-78-0 2-fluorothiophenol 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 
• 1027345-07-8 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride 

Downstream Products

• 1027345-13-6 (R)-N,N-dimethyl-4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanamide 
• 1027345-11-4 (R)-4-(4-morpholino-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide 
• 1027345-12-5 [4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide 
• 1027345-14-7 (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide 

Relevant articles and documents

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

Novel compounds inhibiting anti-apoptosis proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL include compounds of formula (I) and formula (II) disclosed herein, as well as liposome compositions comprising Bcl-2 inhibitor compounds. These compositions are usefu

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.