4-Chloro-5,6,7,8-tetrahydroquinoline

Base Information

Chemical Name:4-Chloro-5,6,7,8-tetrahydroquinoline
CAS No.:133092-34-9
Molecular Formula:C9H10ClN
Molecular Weight:167.64
Hs Code.:2933499090
European Community (EC) Number:822-645-4
DSSTox Substance ID:DTXSID80449155
Wikidata:Q82268535
Mol file:133092-34-9.mol

Synonyms:4-chloro-5,6,7,8-tetrahydroquinoline;133092-34-9;Quinoline, 4-chloro-5,6,7,8-tetrahydro-;4-chloro-5,6,7,8-tetrahydro-quinoline;SCHEMBL2087344;DTXSID80449155;PAEQYSUYGGYPRU-UHFFFAOYSA-N;MFCD18803310;SB68507;AS-50177;CS-0102375;EN300-204076;O11216;A888186

Suppliers and Price of 4-Chloro-5,6,7,8-tetrahydroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-5,6,7,8-tetrahydroquinoline
50mg
$ 330.00

TRC
4-Chloro-5,6,7,8-tetrahydroquinoline
10mg
$ 90.00

Crysdot
4-Chloro-5,6,7,8-tetrahydroquinoline 95+%
25g
$ 3168.00

Crysdot
4-Chloro-5,6,7,8-tetrahydroquinoline 95+%
10g
$ 1683.00

Crysdot
4-Chloro-5,6,7,8-tetrahydroquinoline 95+%
5g
$ 990.00

Crysdot
4-Chloro-5,6,7,8-tetrahydroquinoline 95+%
1g
$ 248.00

Chemenu
4-Chloro-5,6,7,8-tetrahydroquinoline 95%
1g
$ 439.00

Chemenu
4-Chloro-5,6,7,8-tetrahydroquinoline 95%
5g
$ 1062.00

Chemenu
4-Chloro-5,6,7,8-tetrahydroquinoline 95%
10g
$ 1595.00

Biosynth Carbosynth
4-Chloro-5,6,7,8-tetrahydroquinoline
1 g
$ 1115.00

Total 12 raw suppliers

Chemical Property of 4-Chloro-5,6,7,8-tetrahydroquinoline

Chemical Property:

Boiling Point:150 °C(Press: 5 Torr)
PKA:4.46±0.20(Predicted)
PSA：12.89000
Density:1.185±0.06 g/cm3(Predicted)
LogP:2.61380
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:167.0501770
Heavy Atom Count:11
Complexity:138

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5,6,7,8-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=NC=CC(=C2C1)Cl

Technology Process of 4-Chloro-5,6,7,8-tetrahydroquinoline

There total 8 articles about 4-Chloro-5,6,7,8-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 14807-39-7
5,6,7,8-tetrahydroquinolin-4-amine

: 133092-34-9
4-chloro-5,6,7,8-tetrahydroquinoline

Guidance literature:: 5,6,7,8-tetrahydroquinolin-4-amine; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃; for 0.166667h;

With hydrogenchloride; copper(l) chloride; In water; acetic acid; at 0 - 20 ℃; for 17h;
DOI:10.1021/acsmedchemlett.8b00053

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 133092-34-9
4-chloro-5,6,7,8-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: phenol; ammonium carbonate / 110 - 165 °C

2.1: 2 h / Reflux

3.1: platinum(IV) oxide; hydrogen; perchloric acid / acetic acid / 64 h / 20 °C / 2585.81 Torr

4.1: hydrogenchloride / water / 3 h / 70 °C

5.1: hydrogenchloride; sodium nitrite / acetic acid; water / 0.17 h / 0 °C

5.2: 17 h / 0 - 20 °C

With hydrogenchloride; platinum(IV) oxide; perchloric acid; hydrogen; ammonium carbonate; sodium nitrite; phenol; In water; acetic acid; 5.1: |Sandmeyer Reaction / 5.2: |Sandmeyer Reaction;
DOI:10.1021/acsmedchemlett.8b00053

Reference yield:

: N-(7-chloroquinolin-4-yl)-acetamide

: 133092-34-9
4-chloro-5,6,7,8-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: platinum(IV) oxide; hydrogen; perchloric acid / acetic acid / 64 h / 20 °C / 2585.81 Torr

2.1: hydrogenchloride / water / 3 h / 70 °C

3.1: hydrogenchloride; sodium nitrite / acetic acid; water / 0.17 h / 0 °C

3.2: 17 h / 0 - 20 °C

With hydrogenchloride; platinum(IV) oxide; perchloric acid; hydrogen; sodium nitrite; In water; acetic acid; 3.1: |Sandmeyer Reaction / 3.2: |Sandmeyer Reaction;
DOI:10.1021/acsmedchemlett.8b00053