5,6,7,8-Tetrahydroquinolin-4-ol

Base Information

• Chemical Name: 5,6,7,8-Tetrahydroquinolin-4-ol
• CAS No.: 58596-31-9
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.192
• Hs Code.: 2933499090
• European Community (EC) Number: 818-743-1
• Nikkaji Number: J1.989.313H
• Mol file: 58596-31-9.mol

Synonyms:5,6,7,8-Tetrahydroquinolin-4-ol;860231-47-6;5,6,7,8-Tetrahydroquinolin-4(1H)-one;58596-31-9;5,6,7,8-tetrahydro-1h-quinolin-4-one;1,4,5,6,7,8-hexahydroquinolin-4-one;SCHEMBL293154;MFCD28125581;AKOS006355977;AKOS024464710;DS-3210;SY213892;CS-0096033;EN300-264532;Z1203745874

Chemical Property of 5,6,7,8-Tetrahydroquinolin-4-ol

Chemical Property:

• PSA: 32.86000
• LogP: 1.25370
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 250

Purity/Quality:

98.5% ^*data from raw suppliers

5,6,7,8-Tetrahydroquinolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC2=C(C1)C(=O)C=CN2

Technology Process of 5,6,7,8-Tetrahydroquinolin-4-ol

There total 2 articles about 5,6,7,8-Tetrahydroquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 1-hydroxyquinoline-4(1H)-one (72812-97-6) → 1,2,3,4-tetrahydroisoquinoline (635-46-1) + N-methyl-1,2,3,4-tetrahydroquinoline (491-34-9) + 5,6,7,8-tetrahydro-quinolin-4-ol (58596-31-9,860231-47-6)

Guidance literature:

at 240 - 250 ℃; under 44130.5 Torr; Hydrogenation;

Reference yield:

methanol (67-56-1) + 1-hydroxyquinoline-4(1H)-one (72812-97-6) → 1,2,3,4-tetrahydroisoquinoline (635-46-1) + 5,6,7,8-tetrahydro-quinolin-4-ol (58596-31-9,860231-47-6)

Guidance literature:

at 150 - 160 ℃; under 44130.5 Torr; Hydrogenation;

Reference yield:

5,6,7,8-tetrahydro-quinolin-4-ol (58596-31-9,860231-47-6) → 4-chloro-5,6,7,8-tetrahydroquinoline (133092-34-9)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 130 ℃;

upstream raw materials:

methanol

1-hydroxyquinoline-4(1H)-one

Downstream raw materials:

4-chloro-5,6,7,8-tetrahydroquinoline