Oxazolo[5,4-B]pyridine

Base Information

• Chemical Name: Oxazolo[5,4-B]pyridine
• CAS No.: 273-62-1
• Molecular Formula: C6H4N2O
• Molecular Weight: 120.11
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10600419
• Wikidata: Q82496489
• Mol file: 273-62-1.mol

Synonyms:OXAZOLO[5,4-B]PYRIDINE;273-62-1;[1,3]oxazolo[5,4-b]pyridine;MFCD13175184;oxazolopyridine;SCHEMBL141214;DTXSID10600419;Oxazolo[5 pound not4-b]pyridine;BFPLMTPHDFFMTG-UHFFFAOYSA-N;AKOS022184209;DS-18109;SY018739;DB-298853;A876958

Chemical Property of Oxazolo[5,4-B]pyridine

Chemical Property:

• Boiling Point: 199.2±13.0 °C(Predicted)
• PKA: 0.66±0.40(Predicted)
• PSA: 38.92000
• Density: 1.294±0.06 g/cm3(Predicted)
• LogP: 1.22280
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 120.032362755
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

NLT 98% ^*data from raw suppliers

Oxazolo[5,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)OC=N2

Technology Process of Oxazolo[5,4-B]pyridine

There total 2 articles about Oxazolo[5,4-B]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-hydroxypyridine (16867-03-1) + orthoformic acid triethyl ester (122-51-0) → oxazolo<5,4-b>pyridine (273-62-1)

Guidance literature:

With toluene-4-sulfonic acid; at 140 ℃; for 8h;

Reference yield:

→ oxazolo<5,4-b>pyridine (273-62-1)

Guidance literature:

With phosphorus pentoxide; at 240 - 260 ℃; under 2 Torr;

upstream raw materials:

2-amino-3-hydroxypyridine

orthoformic acid triethyl ester

Refernces