(3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride

Base Information

• Chemical Name: (3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride
• CAS No.: 1256240-40-0
• Molecular Formula: C7H14ClNO
• Molecular Weight: 163.64516
• Mol file: 1256240-40-0.mol

Synonyms:(3aR,5s,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride;(3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride;

Chemical Property of (3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride

Chemical Property:

• PSA: 32.26000
• LogP: 1.10750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

rel-(3aR,5R,6aS)-Octahydrocyclopenta[c]pyrrol-5-ol hydrochloride 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride

There total 2 articles about (3aR,5r,6aS)-octahydrocyclopenta[c]pyrrol-5-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate (912563-45-2) → (3aR,5R,6aS)octahydro-cyclopenta[c]pyrrole-5-ol hydrochloride (1256240-40-0,1323417-56-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 12h;

Reference yield:

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (146231-54-1) → (3aR,5R,6aS)octahydro-cyclopenta[c]pyrrole-5-ol hydrochloride (1256240-40-0,1323417-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

2: hydrogenchloride / water; 1,4-dioxane / 12 h

With hydrogenchloride; sodium tetrahydroborate; In 1,4-dioxane; methanol; water;

Reference yield: 1.6%

(E)-4-chloro-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-butenamide + (3aR,5R,6aS)octahydro-cyclopenta[c]pyrrole-5-ol hydrochloride (1256240-40-0,1323417-56-6) → (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-((3aR,5r,6aS)-5-hydroxyhexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-2-butenamide

Guidance literature:

With taxol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 12h;

upstream raw materials:

tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

Downstream raw materials:

[3-(ethoxycarbonyl)isoxazol-5-yl]methyl (3aR,5s,6aS)-5-(4-bromophenoxy)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate