146231-54-1

Basic information

• Product Name: cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
• Synonyms: cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester;tert-Butyl 5-oxo-octahydrocyclopenta-[c]pyrrole-2-carboxylate;2-Boc-5-oxo-hexahydrocyclopenta[c]pyrrole;(3aR,6aS)-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid 1,1-dimethylethyl ester;(3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester;Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-oxo-, 1,1-dimethylethyl ester, (3aR,6aS)-rel-;cis-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;tert-butyl cis-5-oxo-octahydrocyclopenta[c]pyrrole-2-carboxylate
• CAS NO: 146231-54-1
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.28416
• EINECS: -0
• Mol File: 146231-54-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 325.759°C at 760 mmHg
• Flash Point: 150.814°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: 2-8°C
• PKA: -0.82±0.20(Predicted)
• CAS DataBase Reference: cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester(146231-54-1)
• EPA Substance Registry System: cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester(146231-54-1)

Safety Data

• Hazardous Substances Data: 146231-54-1(Hazardous Substances Data)

Usage

General Description

"Cis-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester" is a chemical compound with the molecular formula C14H23NO3. It is commonly used as a building block in organic synthesis and pharmaceutical research. The tert-butyl ester group in the compound makes it a versatile intermediate for the preparation of various derivatives, which can be used in the development of potential drug candidates. The cyclopentane ring and the pyrrole group in the molecule also contribute to its unique structural and chemical properties, making it a valuable component in the synthesis of complex organic molecules. Overall, cis-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester is an important chemical compound with a wide range of potential applications in the field of organic chemistry and drug discovery.

InChI:InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-10(14)5-9(8)7-13/h8-9H,4-7H2,1-3H3

Upstream product

• 147528-20-9 N-(tert-butoxycarbonyl)-N-allyl-3-amino-1-propyne 
• 149191-61-7 Methyl (E)-4-{benzyl[(E)-4-methoxy-4-oxobut-2-enyl]amino}but-2-enoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1469-48-3 cis-1,2,3,6-Tetrahydrophthalimide 
• 96896-09-2 (3aR,6aS)-hexahydrocyclopenta[c]pyrrol-5(1H)-one 
• 474925-37-6 (3aR,7aS)-tert-butyl 3a,4,7,7a-tetrahydro-1H-isoindole-2(3H)-carboxylate 
• 2144-87-8 (cis)-2,3,3a,4,7,7a-hexahydro-1H-isoindole 
• 42268-68-8 allylpropargylamine 
• 15226-74-1 dicobalt octacarbonyl 
• 139228-30-1 (3aS,6aR)-5-Acetoxymethyl-5-benzenesulfonyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 
• 139228-26-5 (3aS,6aR)-5-Benzenesulfonyl-hexahydro-cyclopenta[c]pyrrole-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester 
• 139228-29-8 (3aS,6aR)-5-Benzenesulfonyl-5-hydroxymethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1221439-83-3 tert-butyl (3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 
• 650578-12-4 tert-butyl (3aR,6aS)-5-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole2-carboxylate 
• 1256039-45-8 tert-butyl (3aR,5s,6aS)-5-(aminomethyl)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 
• 1069113-47-8 (3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-5-carboxylic acid 

Relevant articles and documents

An Efficient and Scalable Synthesis of tert-Butyl (3aR,6aS)-5-Oxohexahydrocyclo penta[c]pyrrole-2(1H)-carboxylate: A Pharmacologically Important Intermediate

Hexahydrocyclopentapyrrolone derivatives constitute an important class of bicycles, and it represents an essential pharmacophore for diversified pharmacological activities. A highly efficient process for the synthesis of tert-butyl(3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 1 has been developed. The improved process involves transformation of isoindole 4 to diacid 5, using an inexpensive KMnO4 mediated oxidative cleavage as a key step. The developed process was cost-effective, high yielding, kilogram scalable, and commercially viable for synthesis of 1.

Purine derivative and preparation method and application thereof

The invention discloses a purine derivative and a preparation method and application thereof, belongs to the technical field of medicines, and designs and synthesizes a series of purine derivatives and optical isomers, pharmaceutically acceptable salts, solvates or prodrugs of the purine derivatives. Experiments show that the compound has outstanding anti-cell proliferation activity and DOT1L enzyme inhibition effect, shows good tumor growth inhibition activity in a tumor transplantation tumor model, and has a good application prospect.

ARGINASE INHIBITORS AND METHODS OF USE

Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.