6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol

Base Information

• Chemical Name: 6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol
• CAS No.: 139515-86-9
• Molecular Formula: C9H8BrNO3
• Molecular Weight: 258.071
• Hs Code.: 2906299090
• Mol file: 139515-86-9.mol

Synonyms:1H-Inden-5-ol, 6-bromo-2,3-dihydro-4-nitro-; 6-Bromo-2,3-Dihydro-4-Nitro-1H-Inden-5-Ol

Chemical Property of 6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol

Chemical Property:

• PSA: 66.05000
• LogP: 3.07480
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol

There total 3 articles about 6-broMo-4-nitro-2,3-dihydro-1H-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

6-bromo-2,3-dihydro-1H-inden-5-ol (32337-85-2) → 6-bromo-4-nitro-2,3-dihydro-5-indanol (139515-86-9)

Guidance literature:

With nitric acid; acetic acid; for 1h; Ambient temperature;

DOI:10.1248/cpb.39.2896

Reference yield:

5-hydroxy-2,3-dihydro-1H-indene (1470-94-6) → 6-bromo-4-nitro-2,3-dihydro-5-indanol (139515-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.1 percent / Br₂ / CCl₄ / 1 h / Ambient temperature

2: 52.6 percent / fuming HNO₃, AcOH / 1 h / Ambient temperature

With bromine; nitric acid; acetic acid; In tetrachloromethane;

DOI:10.1248/cpb.39.2896

Reference yield:

→ 6-bromo-4-nitro-2,3-dihydro-5-indanol (139515-86-9)

Guidance literature:

With nitric acid; acetic anhydride; at -5 - 5 ℃; for 8h;

upstream raw materials:

6-bromo-2,3-dihydro-1H-inden-5-ol

5-hydroxy-2,3-dihydro-1H-indene

Downstream raw materials:

3-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-8,9-dihydro-1H,7H-indeno[5,4-b][1,4]oxazin-2-one

Refernces

• 1、 Kajino,Shibouta,Nishikawa,Meguro. "Synthesis and biological activities of new 2-substituted 1,4-benzoxazine derivatives". . p. 2896 - 2905. Retrieved 2007/10/02.