(1R,3S,Z)-3-(tert-butyldiMethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-Methylheptan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexanol

Base Information

• Chemical Name: (1R,3S,Z)-3-(tert-butyldiMethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-Methylheptan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexanol
• CAS No.: 98728-26-8
• Molecular Formula: C33H58O3Si
• Molecular Weight: 530.9
• Mol file: 98728-26-8.mol

Synonyms:(1R,3S,Z)-3-(tert-butyldimethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexanol;

Chemical Property of (1R,3S,Z)-3-(tert-butyldiMethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-Methylheptan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexanol

Chemical Property:

• PSA: 49.69000
• LogP: 8.73420

Purity/Quality:

99% ^*data from raw suppliers

(1R,3S,Z)-3-(tert-butyldimethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3S,Z)-3-(tert-butyldiMethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-Methylheptan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexanol

There total 6 articles about (1R,3S,Z)-3-(tert-butyldiMethylsilyloxy)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-Methylheptan-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-Methylenecyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (1R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester → 1α-tert-butyldimethylsilylether of 1α-25-dihydroxyvitamin D3 (98728-26-8)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1039/c39850000702

Reference yield:

tert-butyldimethylsilyl triflate (133732-91-9) → 1α-tert-butyldimethylsilylether of 1α-25-dihydroxyvitamin D3 (98728-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂

2: 10percent KOH / ethanol

With dmap; potassium hydroxide; In ethanol; dichloromethane;

DOI:10.1039/c39850000702

Reference yield:

1α,3β,25-trihydroxycholesta-5,7-diene (61954-91-4) → 1α-tert-butyldimethylsilylether of 1α-25-dihydroxyvitamin D3 (98728-26-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 4 °C

2: diethyl ether / Irradiation

3: ethanol / 60 °C

4: DMAP / CH₂Cl₂

5: 10percent KOH / ethanol

With pyridine; dmap; potassium hydroxide; In diethyl ether; ethanol; dichloromethane;

DOI:10.1039/c39850000702

upstream raw materials:

tert-butyldimethylsilyl triflate

1α,3β,25-trihydroxycholesta-5,7-diene

(5Z,7E,1S,3R)-3-acetoxy-9,10-seco-5,7,10⁽¹⁹⁾-cholestatriene-1,25-diol

Acetic acid (1S,3R,9S,10R,13R,14R,17R)-1-hydroxy-17-((R)-5-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Downstream raw materials:

(4-Azido-2-nitro-phenylamino)-acetic acid (1R,3S)-3-hydroxy-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyl ester

1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-3-(4-azido-2-nitrophenyl)aminopropyl ether

1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-3-aminopropyl ether

1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

Refernces