1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

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Chemical Name:1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether
CAS No.:168418-07-3
Molecular Formula:C₃₆H₆₁NO₃Si
Molecular Weight:583.971
Hs Code.:

Synonyms:1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

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Technology Process of 1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

There total 1 articles about 1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 107-13-1,25014-41-9
acrylonitrile

: 98728-26-8
1α-tert-butyldimethylsilylether of 1α-25-dihydroxyvitamin D₃

: 168418-07-3
1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In acetonitrile; tert-butyl alcohol; at 4 ℃; for 4h;

Reference yield:

: 168418-07-3
1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

: 1α,25-dihydroxyvitamin D3-3β-3-aminopropyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄, AlCl₃

2: 74.8 percent Spectr_. / ethanol; dimethylsulfoxide / 20 h / 60 °C / in the dark

3: aq. HF / acetonitrile / 3.5 h

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen fluoride; In ethanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 168418-07-3
1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-2-cyanoethyl ether

: 168418-08-4
1α,25-dihydroxyvitamin D3-1-deoxy-1α-t-butyldimethylsilyloxy-3β-3-(4-azido-2-nitrophenyl)aminopropyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄, AlCl₃

2: 74.8 percent Spectr_. / ethanol; dimethylsulfoxide / 20 h / 60 °C / in the dark

With lithium aluminium tetrahydride; aluminium trichloride; In ethanol; dimethyl sulfoxide;