(E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate

Base Information

Chemical Name:(E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate
CAS No.:503559-76-0
Molecular Formula:C₂₉H₃₂FNO₃
Molecular Weight:461.576
Hs Code.:
Mol file:503559-76-0.mol

Synonyms:(E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate;(E)-methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-en-1-yl)nicotinate;3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-2,6-bis(1-methylethyl)-5-(1-propen-1-yl)-, methyl ester

Suppliers and Price of (E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
(E)-methyl4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate
25mg
$ 308.00

Total 7 raw suppliers

Chemical Property of (E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate

Chemical Property:

Boiling Point:555.1±50.0 °C(Predicted)
PKA:3.51±0.31(Predicted)
PSA：48.42000
Density:1.109±0.06 g/cm3(Predicted)
LogP:7.53320

Purity/Quality:

≥95% ^*data from raw suppliers

(E)-methyl4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate

There total 7 articles about (E)-Methyl 4-(2-(benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-enyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 503559-76-0
4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C

2: 92 percent / NH₃ / methanol / 0 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 78 percent / tetrahydrofuran / Heating

5: Red-Al<*> / tetrahydrofuran / 20 °C

6: PCC / CH₂Cl₂ / 20 °C

7: tetrahydrofuran / 20 °C

With pyridine; ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetone; 7: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 470717-48-7
dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate

: 503559-76-0
4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / NH₃ / methanol / 0 °C

2: 95 percent / K₂CO₃ / acetone / Heating

3: 78 percent / tetrahydrofuran / Heating

4: Red-Al<*> / tetrahydrofuran / 20 °C

5: PCC / CH₂Cl₂ / 20 °C

6: tetrahydrofuran / 20 °C

With ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; acetone; 6: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 470717-49-8
dimethyl 2,6-diisopropyl-4-hydroxy-3,5-pyridine-dicarboxylate

: 503559-76-0
4-(2-Benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-((E)-propenyl)-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / K₂CO₃ / acetone / Heating

2: 78 percent / tetrahydrofuran / Heating

3: Red-Al<*> / tetrahydrofuran / 20 °C

4: PCC / CH₂Cl₂ / 20 °C

5: tetrahydrofuran / 20 °C

With potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone; 5: Wittig reaction;
DOI:10.1016/S0960-894X(02)00736-9