3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester
CAS No.:618892-25-4
Molecular Formula:C₂₇H₂₈FNO₄
Molecular Weight:449.522
Hs Code.:
Mol file:618892-25-4.mol

Synonyms:3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester

Suppliers and Price of 3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
3-Pyridinecarboxylicacid,4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-,methylester
100mg
$ 495.00

American Custom Chemicals Corporation
4-[4-FLUORO-2-(PHENYLMETHOXY)PHENYL]-5-FORMYL-2,6-BIS-(1-METHYLETHYL)-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 95.00%
5MG
$ 495.10

Total 3 raw suppliers

Chemical Property of 3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester

Chemical Property:

Vapor Pressure:9.3E-13mmHg at 25°C
Refractive Index:1.57
Boiling Point:564.3°C at 760 mmHg
Flash Point:295.1°C
PSA：65.49000
Density:1.162g/cm³
LogP:6.31260

Purity/Quality:

≥95% ^*data from raw suppliers

3-Pyridinecarboxylicacid,4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-,methylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester

There total 6 articles about 3-Pyridinecarboxylic acid, 4-[4-fluoro-2-(phenylmethoxy)phenyl]-5-formyl-2,6-bis(1-methylethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618892-24-3
4-(2-benzyloxy-4-fluoro-phenyl)-5-hydroxymethyl-2,6-diisopropyl-nicotinic acid methyl ester

: 618892-25-4
4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 618892-25-4
4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C

2: 92 percent / NH₃ / methanol / 0 °C

3: 95 percent / K₂CO₃ / acetone / Heating

4: 78 percent / tetrahydrofuran / Heating

5: Red-Al<*> / tetrahydrofuran / 20 °C

6: PCC / CH₂Cl₂ / 20 °C

With pyridine; ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1016/S0960-894X(02)00736-9

Reference yield:

: 470717-48-7
dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate

: 618892-25-4
4-(2-benzyloxy-4-fluoro-phenyl)-5-formyl-2,6-diisopropyl-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NH₃ / methanol / 0 °C

2: 95 percent / K₂CO₃ / acetone / Heating

3: 78 percent / tetrahydrofuran / Heating

4: Red-Al<*> / tetrahydrofuran / 20 °C

5: PCC / CH₂Cl₂ / 20 °C

With ammonia; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1016/S0960-894X(02)00736-9