2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide

Base Information

• Chemical Name: 2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide
• CAS No.: 103887-32-7
• Molecular Formula: C18H20N2O
• Molecular Weight: 280.3642
• DSSTox Substance ID: DTXSID30545499
• Mol file: 103887-32-7.mol

Synonyms:103887-32-7;2,2-diphenyl-2-(pyrrolidin-3-yl)acetamide;alpha,alpha-Diphenyl-3-pyrrolidineacetamide;2,2-diphenyl-2-pyrrolidin-3-ylacetamide;(S)-A,A-Diphenyl-3-pyrrolidineacetamide;|A,|A-Diphenyl-;2,2-diphenyl-2-(3-pyrrolidinyl)acetamide;SCHEMBL953947;DTXSID30545499;IVJSBKKYHVODFT-UHFFFAOYSA-N;a,a-Diphenyl-3-pyrrolidineacetamide;CS-M0895;?,?-Diphenyl-3-pyrrolidineacetamide;AKOS025248018;CS-17018;2-(3-Pyrrolidinyl)-2,2-diphenylacetamide;2,2-diphenyl-2-pyrrolidin-3-yl-ethanamide;alpha , alpha -Diphenyl-3-pyrrolidineacetamide;A806556;3-(r,s)-(1-carbamoyl-1,1-diphenylmethyl)pyrrolidine;4-METHYLENE-CYCLOPENTANE-1,2-DICARBOXYLICACID

Chemical Property of 2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide

Chemical Property:

• Boiling Point: 488.5±45.0 °C(Predicted)
• PKA: 15.70±0.50(Predicted)
• PSA: 56.11000
• Density: 1.147±0.06 g/cm3(Predicted)
• LogP: 3.54600
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 280.157563266
• Heavy Atom Count: 21
• Complexity: 338

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
• Uses: An impurity arising in the synthesis of Darifenacin (D193500).

Technology Process of 2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide

There total 11 articles about 2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile (133099-11-3,103887-39-4,133099-12-4) → 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7)

Guidance literature:

With sulfuric acid; In water; at 85 - 90 ℃; for 14h;

Reference yield: 58.0%

3-(R,S)-(1-carbamoyl-1,1-diphenyl-methyl)pyrrolidine (103887-32-7) → 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7)

Guidance literature:

3-(R,S)-(1-carbamoyl-1,1-diphenyl-methyl)pyrrolidine; With tartaric acid; In ethanol; for 10 - 20h;

In methanol; at 70 ℃; for 15h;

Reference yield: 58.0%

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate (134002-26-9) → 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7)

Guidance literature:

With sodium hydroxide; In methanol; water;

upstream raw materials:

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(3R)-pyrrolidinol

(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile

Downstream raw materials:

2-[(S)-1-(8-N-benzyl-N-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide

darifenacin hydrochloride

darifenacin

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide