(E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate

Base Information

Chemical Name:(E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate
CAS No.:157188-11-9
Molecular Formula:C₁₇H₂₁FO₄
Molecular Weight:308.35
Hs Code.:
Mol file:157188-11-9.mol

Synonyms:(E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate;Butanedioic acid, [(4-fluorophenyl)methylene]-, 4-(1,1-dimethylethyl) 1-ethyl ester, (E)- (9CI)

Suppliers and Price of (E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
(E)-4-tert-butyl1-ethyl2-(4-fluorobenzylidene)succinate
500mg
$ 275.00

Total 6 raw suppliers

Chemical Property of (E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate

Chemical Property:

Boiling Point:399.9±37.0 °C(Predicted)
PSA：52.60000
Density:1.127±0.06 g/cm3(Predicted)
LogP:3.50400

Purity/Quality:

≥95% ^*data from raw suppliers

(E)-4-tert-butyl1-ethyl2-(4-fluorobenzylidene)succinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate

There total 2 articles about (E)-4-tert-butyl 1-ethyl 2-(4-fluorobenzylidene)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 157188-11-9
2-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, hexane, RT, overnight, 2.) THF, hexane, RT, 24 h

2: 1.) LDA or NaH / 1.) THF, cyclohexane, 0 deg C, 20 min, 2.) THF, cyclohexane, RT, 18 h

With sodium hydride; lithium diisopropyl amide;
DOI:10.1080/00397919308018605

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 77924-28-8
4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate

: 157188-11-9
2-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester

Guidance literature:: With lithium diisopropyl amide; Multistep reaction; 1.) THF, cyclohexane, 0 deg C, 20 min, 2.) THF, cyclohexane, RT, 18 h;
DOI:10.1080/00397919308018605