1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE

Base Information

• Chemical Name: 1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE
• CAS No.: 77924-28-8
• Molecular Formula: C14H27O7P
• Molecular Weight: 338.338
• Hs Code.: 2931900090
• Mol file: 77924-28-8.mol

Synonyms:1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE;1-Ethyl-4-tert-butyl-2-diethylphosphonosuccinate;Butanedioic acid 2-(diethoxyphosphoryl)-1-ethyl-4-tertbutyl ester

Chemical Property of 1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE

Chemical Property:

• Boiling Point: 143 °C(Press: 0.13 Torr)
• PSA: 97.94000
• Density: 1.113±0.06 g/cm3(Predicted)
• LogP: 2.91600
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

1-Ethyl4-(tert-Butyl)2-(diethylphosphono)succinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Ethyl 4-(tert-Butyl) 2-(diethyl phosphono)succinate, is used in the synthesis of Dalesconols A and B, which are the potent immunosuppressant agents.

Technology Process of 1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE

There total 1 articles about 1-ETHYL-4-T-BUTYL-2-DIETHYLPHOSPHONOSUCCINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + bromoacetic acid tert-butyl ester (5292-43-3) → 4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate (77924-28-8)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1002/anie.201002264

Reference yield: 100.0%

2,3-difluorobenzaldehyde (2646-91-5) + 4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate (77924-28-8) → C17H20F2O4

Guidance literature:

4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

2,3-difluorobenzaldehyde; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

Reference yield: 99.0%

2-bromo-5-methoxy-benzaldehyde (7507-86-0) + 4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate (77924-28-8) → 4-(t-butyl) 1-ethyl 2-(2-bromo-5-methoxystyryl)succinate

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201002264

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

bromoacetic acid tert-butyl ester

Downstream raw materials:

2-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester

2-[1-Phenyl-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester

2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester

2-[1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-ethyl ester