Technology Process of tert-butyl (3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylcarbaMate coMpound with tert-butyl (3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-ylcarbaMate (1:1)
There total 6 articles about tert-butyl (3aR,4S,6aS)-octahydrocyclopenta[c]pyrrol-4-ylcarbaMate coMpound with tert-butyl (3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-ylcarbaMate (1:1) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
20% palladium hydroxide-activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 4h;
under 1551.49 Torr;
DOI:10.1016/j.bmcl.2013.06.074
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C
2: triethylamine / dichloromethane / 0.5 h / 25 °C
3: sodium azide / N,N-dimethyl acetamide / 16 h / 90 °C
4: triphenylphosphine; water / tetrahydrofuran / 1 h / 80 °C
5: triethylamine / dichloromethane
6: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 4 h / 20 °C / 1551.49 Torr
With
sodium tetrahydroborate; sodium azide; 20% palladium hydroxide-activated charcoal; water; hydrogen; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide;
4: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.06.074
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0.5 h / 25 °C
2: sodium azide / N,N-dimethyl acetamide / 16 h / 90 °C
3: triphenylphosphine; water / tetrahydrofuran / 1 h / 80 °C
4: triethylamine / dichloromethane
5: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 4 h / 20 °C / 1551.49 Torr
With
sodium azide; 20% palladium hydroxide-activated charcoal; water; hydrogen; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;
3: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.06.074
