(E)-7-broMo-4-chloro-1-ethyl-N-hydroxy-1H-iMidazo[4,5-c]pyridine-2-carbiMidoyl cyanide

Base Information

• Chemical Name: (E)-7-broMo-4-chloro-1-ethyl-N-hydroxy-1H-iMidazo[4,5-c]pyridine-2-carbiMidoyl cyanide
• CAS No.: 842144-06-3
• Molecular Formula: C₁₀H₇BrClN₅O
• Molecular Weight: 328.555
• Mol file: 842144-06-3.mol

Synonyms:(3-bromo-5-nitropyridin-4-yl)ethylamine;2-(7-Bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile;1H-Imidazo[4,5-c]pyridine-2-acetonitrile,7-bromo-1-ethyl;(7-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-acetonitrile;(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-hydroxyimino-acetonitrile;

Chemical Property of (E)-7-broMo-4-chloro-1-ethyl-N-hydroxy-1H-iMidazo[4,5-c]pyridine-2-carbiMidoyl cyanide

Chemical Property:

• Boiling Point: 522.7±60.0 °C(Predicted)
• PKA: 7.20±0.31(Predicted)
• PSA: 87.09000
• Density: 1.86±0.1 g/cm3(Predicted)
• LogP: 2.56898

Purity/Quality:

≥95% ^*data from raw suppliers

(E)-7-bromo-4-chloro-1-ethyl-N-hydroxy-1H-imidazo[4,5-c]pyridine-2-carbimidoylcyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-7-broMo-4-chloro-1-ethyl-N-hydroxy-1H-iMidazo[4,5-c]pyridine-2-carbiMidoyl cyanide

There total 1 articles about (E)-7-broMo-4-chloro-1-ethyl-N-hydroxy-1H-iMidazo[4,5-c]pyridine-2-carbiMidoyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile (842144-05-2) → (7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)hydroxyiminoacetonitrile (842144-06-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 20 ℃; for 0.833333h;

Reference yield: 51.7%

(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)hydroxyiminoacetonitrile (842144-06-3) → 4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine (842144-07-4)

Guidance literature:

(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)hydroxyiminoacetonitrile; With hydroxylamine; triethylamine; In tetrahydrofuran; water; at 90 ℃; for 1.5h;

With triethylamine; In 1,4-dioxane; at 150 ℃; for 1.5h;

DOI:10.1021/jm8004527

upstream raw materials:

(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile

Downstream raw materials:

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine