1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone

Base Information

• Chemical Name: 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone
• CAS No.: 1379670-84-4
• Molecular Formula: C9H4BrCl3N2O
• Molecular Weight: 342.4
• Mol file: 1379670-84-4.mol

Synonyms:1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone;1-(5-Bromo-1h-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethan-1-one;Ethanone, 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloro-

Chemical Property of 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone

Chemical Property:

• PKA: 10.42±0.40(Predicted)
• PSA: 45.75000
• Density: 1.934±0.06 g/cm3(Predicted)
• LogP: 3.87830

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone

There total 2 articles about 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoroacetyl chloride (76-02-8) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone (1379670-84-4)

Guidance literature:

5-bromo-1H-pyrrolo[2,3-b]pyridine; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.166667h;

trifluoroacetyl chloride; In dichloromethane; at 20 ℃;

Reference yield:

trifluoroacetyl chloride (76-02-8) → 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone (1379670-84-4)

Guidance literature:

5-bromo-1H-pyrrolo[2,3-b]pyridine; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.666667h;

trifluoroacetyl chloride; In dichloromethane; at 20 ℃; for 17h;

Reference yield: 100.0%

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone (1379670-84-4) → 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (849068-61-7)

Guidance literature:

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone; With triethylamine; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water; at 20 ℃; for 0.333333h;

upstream raw materials:

trifluoroacetyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

3-[5-(3-fluorobenzyl)-1,3,4-oxadiazol-2-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

3-[5-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

5-bromo-3-[5-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl]-1H-pyrrolo[2,3-b]pyridine

Refernces

• 1、 -. "TRICYCLIC DLK INHIBITORS AND USES THEREOF". Page/Page column 85. . Retrieved 2016/09/26.
• 2、 -. "3-HETARYL-SUBSTITUTED PYRROLO[2,3 B]PYRIDINE DERIVATIVES AS PDK1 INHIBITORS". Paragraph 0254. . Retrieved 2013/09/26.