N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride

Base Information

• Chemical Name: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride
• CAS No.: 1232344-37-4
• Molecular Formula: C20H28ClNOS
• Molecular Weight: 365.967
• Mol file: 1232344-37-4.mol

Synonyms:2-Thiopheneethanamine, N-propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-, hydrochloride (1:1);(S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine hydrochloride;(2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine hydrochloride;(S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl-)ethyl)-tetralin-2-amine hydrochloride;(-)-(S)-5-methoxy-2-[N-n-propyl-N-2-(2-thienyl)ethylamino]tetralin hydrochloride;

Chemical Property of N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride

Chemical Property:

• PSA: 40.71000
• LogP: 5.37070

Purity/Quality:

99% ^*data from raw suppliers

N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]2-thiopheneethanamineHydrochloride(1:1) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride

There total 4 articles about N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

S-5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine L-(+)-tartaric acid + 1-iodo-propane (107-08-4) → (2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine hydrochloride (1232344-37-4)

Guidance literature:

S-5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine L-(+)-tartaric acid; 1-iodo-propane; With sodium carbonate; In N,N-dimethyl-formamide; at 95 - 98 ℃;

With hydrogenchloride; Reagent/catalyst; Solvent; Time;

Reference yield: 95.0%

S-5-methoxy-N-2'-(thien-2-yl)ethyltetralin-2-amine L-(+)-tartrate + 1-iodo-propane (107-08-4) → (2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine hydrochloride (1232344-37-4)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 95 - 98 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield: 84.8%

(-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetraline (1232344-40-9) + propionic acid (802294-64-0,79-09-4) → (2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine hydrochloride (1232344-37-4)

Guidance literature:

propionic acid; With sodium tetrahydroborate; In toluene; at 0 - 25 ℃; for 1.5h;

(-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetraline; In toluene; at 20 - 95 ℃; for 3h;

upstream raw materials:

(-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetraline

propionic acid

(2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine

1-iodo-propane

Downstream raw materials:

rotigotine hydrochloride

rotigotine