2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
• CAS No.: 188860-26-6
• Molecular Formula: C27H28N6O2
• Molecular Weight: 468.558
• DSSTox Substance ID: DTXSID80436348
• Nikkaji Number: J821.463H
• ChEMBL ID: CHEMBL125284
• Mol file: 188860-26-6.mol

Synonyms:188860-26-6;2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole;2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-;DMA (hydrochloride);CHEMBL125284;SCHEMBL1552158;DTXSID80436348;BMRRDFCQNOZNNR-UHFFFAOYSA-N;NSC822900;AKOS040744066;CS-1309;NSC-822900;AS-80660;HY-15621;F77828;2'-(3,4-Dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi[1H-benzimidazole];2'-(3,4-Dimethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole;2'-(3,4-Dimethoxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzimidazole;2-(3,4-dimethoxyphenyl)-5-(5-(4 methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-benzimidazole

Chemical Property of 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Chemical Property:

• PSA: 82.30000
• LogP: 4.54510
• Storage Temp.: 2-8°C
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 468.22737416
• Heavy Atom Count: 35
• Complexity: 705

Purity/Quality:

99% ^*data from raw suppliers

DMA 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=C(C=C6)OC)OC

Technology Process of 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

There total 7 articles about 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5-formyl-2-(3,4-dimethoxyphenyl)-3H-benzimidazole (1248696-03-8) + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (188860-26-6)

Guidance literature:

With sodium metabisulfite; In ethanol; water; for 6h; Reflux;

DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (188860-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 110 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr

3: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

5-(4-methylpiperazine-1-yl)-2-nitroaniline (23491-48-7) → 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (188860-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr

2: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; palladium 10% on activated carbon; hydrogen; In ethanol; water;

DOI:10.1016/j.ejmech.2010.11.046

upstream raw materials:

1-methyl-piperazine

5-formyl-2-(3,4-dimethoxyphenyl)-3H-benzimidazole

4-(4-methylpiperazino)-1,2-diaminobenzene

2-(3,4-dimethoxyphenyl)-1H-benzimidazole-6-carbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 188860-26-6 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send