XL-518 raceMate

Base Information

Chemical Name:XL-518 raceMate
CAS No.:934662-91-6
Molecular Formula:C₂₁H₂₁F₃IN₃O₂
Molecular Weight:531.316
Hs Code.:2933399990
Mol file:934662-91-6.mol

Synonyms:CS-1043; GDC-0973 racemate||GDC 0973|XL 518|GDC0973|XL518; GDC0973; GDC-0973 racemate

Suppliers and Price of XL-518 raceMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Cobimetinibracemate 98+%
10mg
$ 550.00

Crysdot
Cobimetinibracemate 98+%
5mg
$ 380.00

ChemScene
Cobimetinibracemate 99.09%
50mg
$ 960.00

ChemScene
Cobimetinibracemate 99.09%
5mg
$ 216.00

ChemScene
Cobimetinibracemate 99.09%
10mg
$ 360.00

Chemenu
(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone 98%
50mg
$ 458.00

ApexBio Technology
Cobimetinib(racemate)
5mg
$ 236.00

Total 10 raw suppliers

Chemical Property of XL-518 raceMate

Chemical Property:

PSA：64.60000
LogP:4.12080

Purity/Quality:

97% ^*data from raw suppliers

Cobimetinibracemate 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of XL-518 raceMate

There total 8 articles about XL-518 raceMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R,S)-cobimetinib hydrochloride

: 934662-91-6,934660-93-2
cobimetinib

Guidance literature:: With sodium hydrogencarbonate; In diethyl ether; water; for 2h;

Reference yield:

: 153749-89-4
2-cyanopiperidine-1-carboxylic acid tert-butyl ester

: 934662-91-6,934660-93-2
cobimetinib

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide / tetrahydrofuran / 1.08 h / -78 - -73 °C

1.2: 2.58 h / -78 - -73 °C

2.1: acetic acid; sodium cyanoborohydride / ethanol / 30 h / 70 °C

3.1: palladium on activated charcoal; hydrogen / ethanol / 2 h / 2625.26 Torr

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

4.2: 20 °C

5.1: hydrogenchloride / water; methanol / 3 h

6.1: sodium hydrogencarbonate / water; diethyl ether / 2 h

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetonitrile;

Reference yield:

: tert-butyl 2-[1-(benzyloxycarbonyl)-3-hydroxy-3-azetidinyl]-2-cyano-1-piperidinecarboxylate

: 934662-91-6,934660-93-2
cobimetinib

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium cyanoborohydride / ethanol / 30 h / 70 °C

2.1: palladium on activated charcoal; hydrogen / ethanol / 2 h / 2625.26 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: 20 °C

4.1: hydrogenchloride / water; methanol / 3 h

5.1: sodium hydrogencarbonate / water; diethyl ether / 2 h

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; diethyl ether; ethanol; water; acetonitrile;