1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: 1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• CAS No.: 934666-39-4
• Molecular Formula: C₁₃H₂₄N₂O₃
• Molecular Weight: 256.345
• Mol file: 934666-39-4.mol

Synonyms:(S)-2-(3-Hydroxyazetidin-3-yl)piperidine-1-carboxylic acid tert-butyl ester;1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

Chemical Property of 1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 381.4±42.0 °C(Predicted)
• PKA: 13.98±0.20(Predicted)
• PSA: 61.80000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 1.37700

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(3-Hydroxyazetidin-3-yl)piperidine-1-carboxylicacidtert-butylester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate

There total 32 articles about 1,1-DiMethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C15H23F3N2O4 → (R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate (934666-39-4,934666-06-5)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 20 - 35 ℃;

Reference yield: 98.0%

1,1-dimethylethyl 2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate (934664-27-4) → (R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate (934666-39-4,934666-06-5)

Guidance literature:

With hydrogen; palladium on activated carbon; In methanol; for 15h; under 760.051 Torr;

Reference yield: 96.3%

1,1-dimethylethyl (2S)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate (934665-55-1) → 1,1-dimethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate (934666-39-4,934666-06-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 35 ℃; for 3h; Concentration;

upstream raw materials:

1,1-dimethylethyl (2S)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate

1,1-dimethylethyl 2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate

1,1-dimethylethyl (2S)-2-(1-{[(phenylmethyl)oxy]carbonyl}-3-{[(2R)-3,3,3-trifluoro-2-(methyloxy)-2-phenylpropanoyl]oxy}azetidin-3-yl)piperidine-1-carboxylate

pipecolinic acid

Downstream raw materials:

cobimetinib

tert-butyl (S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}perhydropyridine-1-carboxylate

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