Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

Base Information

Chemical Name:Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate
CAS No.:897732-93-3
Molecular Formula:C₂₁H₂₉N₅O₆S
Molecular Weight:479.557
Hs Code.:
UNII:345354O7AT
ChEMBL ID:CHEMBL1951032
DSSTox Substance ID:DTXSID10237885
Metabolomics Workbench ID:153137
Pharos Ligand ID:Y2HYSMUQAMS4
Wikidata:Q27893071
Mol file:897732-93-3.mol

Synonyms:APD597

Suppliers and Price of Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
APD597(JNJ-38431055) >98%
1 g
$ 1900.00

Crysdot
APD597 98+%
100mg
$ 1996.00

Crysdot
APD597 98+%
50mg
$ 1426.00

Crysdot
APD597 98+%
10mg
$ 475.00

Crysdot
APD597 98+%
5mg
$ 333.00

ChemScene
APD597 99.97%
50mg
$ 290.00

ChemScene
APD597 99.97%
10mg
$ 140.00

ChemScene
APD597 99.97%
5mg
$ 80.00

ChemScene
APD597 99.97%
100mg
$ 450.00

Cayman Chemical
APD597
50mg
$ 568.00

Total 18 raw suppliers

Chemical Property of Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

Chemical Property:

Boiling Point:648.3±55.0 °C(Predicted)
PKA:2.43±0.10(Predicted)
PSA：141.22000
Density:1.311±0.06 g/cm3(Predicted)
LogP:3.81560
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:479.18385484
Heavy Atom Count:33
Complexity:740

Purity/Quality:

99%, ^*data from raw suppliers

APD597(JNJ-38431055) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC
Recent ClinicalTrials:A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (Explores What the Body Does to the Drug), and Pharmacodynamics (Explores What a Drug Does to the Body) of JNJ-38431055 in Volunteers With Type 2 Diabetes Mellitus

Technology Process of Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

There total 2 articles about Isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 897732-75-1
2-methyl-6-(methylsulfonyl)pyridin-3-amine

: 897732-25-1
4-(6-chloro-5-methoxy-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid isopropyl ester

: 897732-93-3
APD597

Guidance literature:: With sodium t-butanolate; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; palladium diacetate; In 1,4-dioxane; at 120 ℃; for 2h; Irradiation;