Technology Process of PF-04957325
There total 8 articles about PF-04957325 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Thiazole-2-carbaldehyde; 3-[(2R)-morpholin-2-ylmethyl]-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine;
In
2-methyltetrahydrofuran;
for 1h;
Inert atmosphere;
With
sodium tris(acetoxy)borohydride;
In
2-methyltetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / 15 h / 20 °C
1.2: 25 °C
2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / 20 - 45 °C / Inert atmosphere
3.1: acetic acid; iron / 1.25 h / 50 °C
4.1: sodium carbonate / acetonitrile / 36 h / 80 °C
5.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C
5.2: pH 9 - 10
6.1: ammonium hydroxide / 2-methyltetrahydrofuran / 80 °C / Sealed tube
7.1: hydrogen / 10% Pd(OH)2/C / 2-methyltetrahydrofuran / 55 °C / 2585.81 Torr
8.1: 2-methyltetrahydrofuran / 1 h / Inert atmosphere
8.2: 20 °C
With
hydrogenchloride; ammonium hydroxide; phosphoric acid; hydrogen; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; trichlorophosphate;
10% Pd(OH)2/C;
In
2-methyltetrahydrofuran; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; iron / 1.25 h / 50 °C
2.1: sodium carbonate / acetonitrile / 36 h / 80 °C
3.1: hydrogenchloride; sodium nitrite / water; 2-methyltetrahydrofuran / 1.17 h / 20 °C
3.2: pH 9 - 10
4.1: ammonium hydroxide / 2-methyltetrahydrofuran / 80 °C / Sealed tube
5.1: hydrogen / 10% Pd(OH)2/C / 2-methyltetrahydrofuran / 55 °C / 2585.81 Torr
6.1: 2-methyltetrahydrofuran / 1 h / Inert atmosphere
6.2: 20 °C
With
hydrogenchloride; ammonium hydroxide; hydrogen; iron; sodium carbonate; acetic acid; sodium nitrite;
10% Pd(OH)2/C;
In
2-methyltetrahydrofuran; water; acetonitrile;
