AM-1638

Base Information

Chemical Name:AM-1638
CAS No.:1142214-62-7
Molecular Formula:C₃₃H₃₅FO₄
Molecular Weight:514.637
Hs Code.:

Synonyms:

Suppliers and Price of AM-1638

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of AM-1638

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of AM-1638

There total 19 articles about AM-1638 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393841-41-2
C₃₄H₃₇FO₄

: 1142214-62-7
[3H]-AM 1638

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1021/ml300133f

Reference yield:

: 1142223-37-7
4-(chloromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 1142223-08-2,1142224-62-1
methyl (3S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate

: 1142214-62-7
[3H]-AM 1638

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300133f

Reference yield:

: 29415-97-2
methyl 3-bromo-4-hydroxybenzoate

: 1142214-62-7
[3H]-AM 1638

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 2 h / 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / N,N-dimethyl-formamide; water / 21 h / 75 °C / Inert atmosphere

3.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

4.1: triethylamine; dmap / dichloromethane / 0.33 h

4.2: 3 h / 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3.5 h / 0 - 40 °C

7.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9.1: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; potassium phosphate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium diacetate; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ml300133f