AM-1638

Base Information

• Chemical Name: AM-1638
• CAS No.: 1142214-62-7
• Molecular Formula: C₃₃H₃₅FO₄
• Molecular Weight: 514.637
• Mol file: 1142214-62-7.mol

Synonyms:

Chemical Property of AM-1638

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AM-1638

There total 19 articles about AM-1638 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H37FO4 (1393841-41-2) → [3H]-AM 1638 (1142214-62-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1021/ml300133f

Reference yield:

4-(chloromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl (1142223-37-7) + methyl (3S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate (1142223-08-2,1142224-62-1) → [3H]-AM 1638 (1142214-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/ml300133f

Reference yield:

methyl 3-bromo-4-hydroxybenzoate (29415-97-2) → [3H]-AM 1638 (1142214-62-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dichloromethane / 2 h / 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / N,N-dimethyl-formamide; water / 21 h / 75 °C / Inert atmosphere

3.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

4.1: triethylamine; dmap / dichloromethane / 0.33 h

4.2: 3 h / 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3.5 h / 0 - 40 °C

7.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9.1: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; potassium phosphate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium diacetate; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/ml300133f

upstream raw materials:

methyl 3-bromo-4-hydroxybenzoate

methyl 3-bromo-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-hydroxybenzoate