1393841-41-2 Usage
General Description
The chemical C34H37FO4 is a molecule of fluocinolone acetonide, which is a synthetic steroid used primarily as a topical anti-inflammatory and anti-itching agent. It belongs to the class of corticosteroids and is often used in the treatment of various skin conditions, such as eczema, psoriasis, and allergic reactions. Fluocinolone acetonide works by reducing inflammation, suppressing the immune response, and relieving itching and swelling. It is commonly found in topical creams, ointments, and gels for application to the skin, and it is generally well-tolerated with few systemic side effects when used as directed.
Check Digit Verification of cas no
The CAS Registry Mumber 1393841-41-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,3,8,4 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1393841-41:
(9*1)+(8*3)+(7*9)+(6*3)+(5*8)+(4*4)+(3*1)+(2*4)+(1*1)=182
182 % 10 = 2
So 1393841-41-2 is a valid CAS Registry Number.
1393841-41-2Relevant articles and documents
Improving the pharmacokinetics of GPR40/FFA1 full agonists
Du, Xiaohui,Dransfield, Paul J.,Lin, Daniel C.-H.,Wong, Simon,Wang, Yingcai,Wang, Zhongyu,Kohn, Todd,Yu, Ming,Brown, Sean P.,Vimolratana, Marc,Zhu, Liusheng,Li, An-Rong,Su, Yongli,Jiao, Xianyun,Liu, Jiwen,Swaminath, Gayathri,Tran, Thanhvien,Luo, Jian,Zhuang, Run,Zhang, Jane,Guo, Qi,Li, Frank,Connors, Richard,Medina, Julio C.,Houze, Jonathan B.
supporting information, p. 384 - 389 (2014/05/06)
We recently reported the discovery of a potent GPR40 full agonist AM-1638 (1). Herein, we describe our efforts in improving the drug-like properties of the full agonists through the systematic introduction of polar groups in the C-, D-, and A-rings. This led to the discovery of new GPR40 full agonists with significantly improved pharmacokinetic propeties. Compound 8 and 20 also showed potent in vivo efficacy in oral glucose tolerance tests in mice in addition to the improvement in properties.
