Rolapitant Hydrochloride

Base Information

Chemical Name:Rolapitant Hydrochloride
CAS No.:914462-92-3
Molecular Formula:C25H29ClF6N2O3
Molecular Weight:554.96
Hs Code.:
European Community (EC) Number:682-730-5
UNII:57O5S1QSAQ
ChEMBL ID:CHEMBL3707330
DSSTox Substance ID:DTXSID70238570
NCI Thesaurus Code:C97955
RXCUI:1673367
Wikidata:Q27162902
Mol file:914462-92-3.mol

Synonyms:(5S,8S)-8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro(4.5)decan-2-one;8-((1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro(4,5)decan-2-one;rolapitant;SCH 619734;Varubi

Suppliers and Price of Rolapitant Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RolapitantHydrochlorideHydrate
5mg
$ 275.00

Matrix Scientific
Rolapitant 95+%
1g
$ 11880.00

Biosynth Carbosynth
Rolapitant hydrochloride monohydrate
50 mg
$ 350.00

Biosynth Carbosynth
Rolapitant hydrochloride monohydrate
25 mg
$ 250.00

Biosynth Carbosynth
Rolapitant hydrochloride monohydrate
10 mg
$ 170.00

Biosynth Carbosynth
Rolapitant hydrochloride monohydrate
100 mg
$ 450.00

Biosynth Carbosynth
Rolapitant hydrochloride monohydrate
250 mg
$ 600.00

American Custom Chemicals Corporation
ROLAPITANT 95.00%
1G
$ 10905.30

American Custom Chemicals Corporation
ROLAPITANT 95.00%
5MG
$ 498.99

AK Scientific
Rolapitanthydrochloride
25mg
$ 387.00

Total 46 raw suppliers

Chemical Property of Rolapitant Hydrochloride

Chemical Property:

PSA：59.59000
LogP:7.12480
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:554.1770895
Heavy Atom Count:37
Complexity:731

Purity/Quality:

99%, ^*data from raw suppliers

RolapitantHydrochlorideHydrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OCC2(CCC3(CCC(=O)N3)CN2)C4=CC=CC=C4.O.Cl
Isomeric SMILES:C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4.O.Cl
Recent ClinicalTrials:Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving Chemotherapy
Recent EU Clinical Trials:A Phase 3, Multicenter, Randomized, Double-Blind, Active-Controlled Study of the Safety and Efficacy of Rolapitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Subjects Receiving Highly Emetogenic Chemotherapy (HEC)
Description Rolapitant hydrochloride hydrate, originally discovered by Schering-Plough and later developed by TESARO, Inc., was approved by the FDA in September 2015 for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in combination with other antiemetic agents. Rolapitant is a highly selective NK-1 receptor antagonist, exhibiting >1000- fold selectivity for NK-1 over human NK-2 and NK-3 receptors in vitro. In contrast to other NK-1 inhibitors that play an essential role in delayed CINV therapy, rolapitant shows no inhibition of CYP3A4, eliminating the need for concern when coadministering with CYP34A substrates. Additionally, rolapitant is an orally active agent with a relatively long half-life (180 h), providing potential opportunities for single- and prechemotherapy-based treatments. In three large clinical trials involving patients receiving moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC), subjects using rolapitant as a cotherapy with granisetron and dexamethasone showed a significant improvement in complete response compared to those receiving treatments of granisetron and dexamethasone.
Uses Rolapitant Hydrochloride Hydrate is a raw material for pharmaceutical formulations.

Technology Process of Rolapitant Hydrochloride

There total 1 articles about Rolapitant Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552292-08-7
Rolapitant

: 914462-92-3
(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride monohydrate

Guidance literature:: With hydrogenchloride; water; In ethanol; isopropyl alcohol; at 0 - 25 ℃; for 1.41667h; Product distribution / selectivity;