Rolapitant hydrochloride

Base Information

• Chemical Name: Rolapitant hydrochloride
• CAS No.: 858102-79-1
• Molecular Formula: C₂₅H₂₆F₆N₂O₂*ClH
• Molecular Weight: 536.945
• Mol file: 858102-79-1.mol

Synonyms:Rolapitant hydrochloride

Chemical Property of Rolapitant hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Rolapitant hydrochloride

There total 17 articles about Rolapitant hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(5R,8S)-8-[1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-8-phenyl-1,7-diaza-spiro[4.5]dec-9-en-2-one, hydrochloride → Rolapitant hydrochloride (858102-79-1)

Guidance literature:

(5R,8S)-8-[1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-8-phenyl-1,7-diaza-spiro[4.5]dec-9-en-2-one, hydrochloride; With sodium hydroxide; In water; toluene; for 0.25h;

With palladium 10% on activated carbon; hydrogen; under 3102.97 - 4137.29 Torr;

With hydrogenchloride;

Reference yield:

C25H26F6N2O3 (1065272-51-6) → Rolapitant hydrochloride (858102-79-1)

Guidance literature:

C₂₅H₂₆F₆N₂O₃; With hydrogen; Raney Nickel; In ethanol; at 50 ℃; under 3750.38 Torr; Industry scale; Autoclave;

With hydrogenchloride; In ethanol; water; for 0.583333h;

Reference yield:

methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate (1065272-06-1) → Rolapitant hydrochloride (858102-79-1)

Guidance literature:

methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate; With acetic acid; zinc; at 20 - 60 ℃;

With hydrogenchloride; In ethanol; water; isopropyl alcohol; toluene; at 0 - 25 ℃;

upstream raw materials:

(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride monohydrate

methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

C₂₅H₂₆F₆N₂O₃

L-Pyroglutamic acid

Refernces

• 1、 -. "PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS". Page/Page column 14-15. . Retrieved 2010/04/30.