Rolapitant hydrochloride

Base Information

Chemical Name:Rolapitant hydrochloride
CAS No.:858102-79-1
Molecular Formula:C₂₅H₂₆F₆N₂O₂*ClH
Molecular Weight:536.945
Hs Code.:

Synonyms:Rolapitant hydrochloride

Suppliers and Price of Rolapitant hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Rolapitant hydrochloride

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Rolapitant hydrochloride

There total 17 articles about Rolapitant hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (5R,8S)-8-[1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-8-phenyl-1,7-diaza-spiro[4.5]dec-9-en-2-one, hydrochloride

: 858102-79-1
Rolapitant hydrochloride

Guidance literature:: (5R,8S)-8-[1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-8-phenyl-1,7-diaza-spiro[4.5]dec-9-en-2-one, hydrochloride; With sodium hydroxide; In water; toluene; for 0.25h;

With palladium 10% on activated carbon; hydrogen; under 3102.97 - 4137.29 Torr;

With hydrogenchloride;

Reference yield:

: 1065272-51-6
C₂₅H₂₆F₆N₂O₃

: 858102-79-1
Rolapitant hydrochloride

Guidance literature:: C₂₅H₂₆F₆N₂O₃; With hydrogen; Raney Nickel; In ethanol; at 50 ℃; under 3750.38 Torr; Industry scale; Autoclave;

With hydrogenchloride; In ethanol; water; for 0.583333h;

Reference yield:

: 1065272-06-1
methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

: 858102-79-1
Rolapitant hydrochloride

Guidance literature:: methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate; With acetic acid; zinc; at 20 - 60 ℃;

With hydrogenchloride; In ethanol; water; isopropyl alcohol; toluene; at 0 - 25 ℃;