(S)-1,2-DIMETHYL-PIPERAZINE

Base Information

• Chemical Name: (S)-1,2-DIMETHYL-PIPERAZINE
• CAS No.: 485841-52-9
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 2933599090
• Mol file: 485841-52-9.mol

Synonyms:1,2-Distearin,S;(S)-(-)-1,2-distearoyl-sn-glycerol;(S)-2,3-bis-octadecanoyloxy-propan-1-ol;DG(18:0/18:0/0:0);1,2-distearoyl-sn-glycerol;(S)-1,2-distearoylglycerol;L-1,2-Distearin;(-)(S)-Glycerin-1,2-distearat;Diacylglycerol(18:0/18:0);1,2-di-O-stearoyl-sn-glycerol;(2S)-1,2-Dimethyl-piperazine;(S)-2,3-bis-stearoyloxy-propan-1-ol;1,2-dioctadecanoyl-sn-glycerol;2-dimethylpiperazine;(S)-1,2-dioctadecanoylglycerol;(2S)-1,2-bis-O-stearylglycerol;

Chemical Property of (S)-1,2-DIMETHYL-PIPERAZINE

Chemical Property:

• Boiling Point: 147.0±8.0 °C(Predicted)
• PKA: 9.31±0.40(Predicted)
• PSA: 15.27000
• Density: 0.855±0.06 g/cm3(Predicted)
• LogP: 0.17660
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(S)-1,2-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1,2-DIMETHYL-PIPERAZINE

There total 2 articles about (S)-1,2-DIMETHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (S)-3,4-dimethylpiperazine-1-carboxylate (1152110-42-3) → (2S)-1,2-dimethylpiperazine (485841-52-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) → (2S)-1,2-dimethylpiperazine (485841-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; methanol / 2.5 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane

With trifluoroacetic acid; In methanol; dichloromethane; water;

Reference yield: 55.0%

(2S)-1,2-dimethylpiperazine (485841-52-9) + 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide (503555-53-1) → 8-({5-chloro-2-[(3S)-3,4-dimethylpiperazin-1-yl]isonicotinoyl}amino)-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide (623586-03-8)

Guidance literature:

In ethanol; at 100 ℃; for 72h;

DOI:10.1016/j.bmc.2009.10.040

upstream raw materials:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

tert-butyl (S)-3,4-dimethylpiperazine-1-carboxylate

Downstream raw materials:

8-({5-chloro-2-[(3S)-3,4-dimethylpiperazin-1-yl]isonicotinoyl}amino)-1-(4-fluoro-phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

(S)-4-(3,4-dimethylpiperazin-1-yl)benzaldehyde

(5R,6S)-5,6-bis(4-chlorophenyl)-2-[((2S,5R)-2-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole