3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3

Base Information

• Chemical Name: 3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3
• CAS No.: 133191-10-3
• Molecular Formula: C30H47NO2
• Molecular Weight: 453.7
• Mol file: 133191-10-3.mol

Synonyms:3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3;Propanenitrile, 3-[[(3β,5Z,7E)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-3-yl]oxy]-;3-[(1S,3Z)-3-[(2E)-2-[(1R,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexyl]oxypropanenitrile

Chemical Property of 3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

3-O-(2-Cyanoethyl)-25-hydroxyvitaminD3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3

There total 2 articles about 3-O-(2-Cyanoethyl)-25-hydroxyvitaMin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

calcidiol (19356-17-3) + acrylonitrile (107-13-1,25014-41-9) → 3-(((S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)propanenitrile (133191-10-3)

Guidance literature:

With potassium hydride; In dichloromethane; acetonitrile; tert-butyl alcohol; at 6 ℃; for 1h;

Reference yield: 68.0%

(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol + acrylonitrile (107-13-1,25014-41-9) → 3-(((S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)propanenitrile (133191-10-3)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In acetonitrile; tert-butyl alcohol; at 4 ℃; for 2.5h;

Reference yield: 82.0%

3-(((S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)propanenitrile (133191-10-3) → C30H51NO2

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 1.08333h; Inert atmosphere;

upstream raw materials:

calcidiol

acrylonitrile

Refernces

• 1、 -. "RNAi VITAMIN D CONJUGATES". Paragraph 0177. . Retrieved 2016/05/24.
• 2、 -. "THERAPEUTIC VITAMIN D CONJUGATES". Paragraph 0236. . Retrieved 2016/05/19.