(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate
CAS No.:942145-05-3
Molecular Formula:C19H27ClN4O3
Molecular Weight:394.89568
Hs Code.:
Mol file:942145-05-3.mol

Synonyms:(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)Methyl)piperidine-1-carboxylate

Suppliers and Price of (R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Chemical Property:

PSA：88.52000
LogP:4.74576

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

There total 7 articles about (R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942145-04-2
(R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-(methylsulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate

: 942145-05-3
(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1016/j.bmcl.2009.11.066

Reference yield:

: 942142-74-7
(R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

: 942145-05-3
(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 20 °C

3.1: triethylamine / dichloromethane / 3 h / -5 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 16 h / 80 °C

With sodium tetrahydroborate; sodium azide; sodium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml200137x

Reference yield:

: 884510-86-5
(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 942145-05-3
(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: R-CBS-oxazaborolidine / tetrahydrofuran; toluene / -15 °C / Inert atmosphere

2.2: -15 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 0 - 20 °C

4.1: sodium tetrahydroborate / methanol / 20 °C

5.1: triethylamine / dichloromethane / 3 h / -5 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 16 h / 80 °C

With sodium tetrahydroborate; n-butyllithium; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/ml200137x