1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)-

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)-
• CAS No.: 884510-86-5
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.345
• Mol file: 884510-86-5.mol

Synonyms:1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)-;(R)-tert-Butyl 3-(N-methoxy-N-methylcarbamoyl)piperidine-1-carboxylate

Chemical Property of 1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)-

Chemical Property:

• Vapor Pressure: 6.87E-05mmHg at 25°C
• Boiling Point: 343.8°C at 760 mmHg
• Flash Point: 161.7°C
• PSA: 59.08000
• Density: 1.106g/cm³
• LogP: 1.59120

Purity/Quality:

NLT 98% ^*data from raw suppliers

3R-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)-

There total 3 articles about 1-Piperidinecarboxylic acid, 3-[(MethoxyMethylaMino)carbonyl]-, 1,1-diMethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (R)-1-Boc-nipecotic acid (163438-09-3) → (R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (884510-86-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine;

DOI:10.1016/j.tetlet.2016.04.102

Reference yield: 91.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (884510-86-5)

Guidance literature:

(R)-1-Boc-nipecotic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 ℃; for 1h;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

(R)-1-Boc-nipecotic acid (163438-09-3) + N,0-dimethylhydroxylamine (1117-97-1) → (R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (884510-86-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(R)-1-Boc-nipecotic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

(R)-tert-butyl 3-benzoylpiperidine-1-carboxylate

(R)-tert-butyl 3-((benzofuran-7-yl)carbonyl)piperidine-1-carboxylate

(R)-tert-butyl 3-(6-fluoro-3'-methylbiphenylcarbonyl)piperidine-1-carboxylate

(3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine

Refernces

• 1、 Yuan, Jing,Simpson, Robert D.,Zhao, Wei,Tice, Colin M.,Xu, Zhenrong,Cacatian, Salvacion,Jia, Lanqi,Flaherty, Patrick T.,Guo, Joan,Ishchenko, Alexey,Wu, Zhongren,McKeever, Brian M.,Scott, Boyd B.,Bukhtiyarov, Yuri,Berbaum, Jennifer,Panemangalore, Reshma,Bentley, Ross,Doe, Christopher P.,Harrison, Richard K.,McGeehan, Gerard M.,Singh, Suresh B.,Dillard, Lawrence W.,Baldwin, John J.,Claremon, David A.. "Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket". scheme or table. p. 4836 - 4843. Retrieved 2011/09/16.
• 2、 -. "Renin Inhibitors". Page/Page column 46. . Retrieved 2010/12/29.