SAR125844

Base Information

Chemical Name:SAR125844
CAS No.:1116743-46-4
Molecular Formula:C25H23FN8O2S2
Molecular Weight:550.64
Hs Code.:
Mol file:1116743-46-4.mol

Synonyms:SAR125884;SAR125844;SAR125844 /SAR-125844;SAR125844; SAR 125844; SAR-125844;SAR125884 hydrochlorid (1116743-46-4(free base));1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea;Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-;1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea

Suppliers and Price of SAR125844

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
SAR125844 >98%
1 g
$ 2200.00

ChemScene
SAR125844 99.03%
50mg
$ 750.00

ChemScene
SAR125844 99.03%
10mg
$ 190.00

ChemScene
SAR125844 99.03%
5mg
$ 120.00

ChemScene
SAR125844 99.03%
100mg
$ 1300.00

Biorbyt Ltd
SAR125844 >98%
1 g
$ 3282.70

Biorbyt Ltd
SAR125844 >98%
250 mg
$ 1802.00

Biorbyt Ltd
SAR125844 >98%
100 mg
$ 1208.70

Total 12 raw suppliers

Chemical Property of SAR125844

Chemical Property:

PSA：163.11000
LogP:4.54680

Purity/Quality:

99%, ^*data from raw suppliers

SAR125844 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of SAR125844

There total 5 articles about SAR125844 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1116743-29-3
3-chloro-6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine

: 1116743-47-5
1-(2-morpholin-4-ylethyl)-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea

: 1116743-46-4
1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: With sodium tetrahydroborate; triethylamine; In N,N-dimethyl-formamide; at 20 - 95 ℃; for 4h;
DOI:10.1021/acs.jmedchem.6b00280

Reference yield:

: 7170-77-6
2-amino-6-thiocyanatobenzothiazole

: 1116743-46-4
1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 h / 20 °C

2: tetrahydrofuran / 24 h / 20 °C

3: potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol / water; ethanol / 16 h / 20 °C / Inert atmosphere

4: triethylamine; sodium tetrahydroborate / N,N-dimethyl-formamide / 4 h / 20 - 95 °C

With sodium tetrahydroborate; potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00280

Reference yield:

: 1116743-49-7
(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

: 1116743-46-4
1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / 20 °C

2: potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol / water; ethanol / 16 h / 20 °C / Inert atmosphere

3: triethylamine; sodium tetrahydroborate / N,N-dimethyl-formamide / 4 h / 20 - 95 °C

With sodium tetrahydroborate; potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00280