(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

Base Information

Chemical Name:(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester
CAS No.:1116743-49-7
Molecular Formula:C₁₅H₉N₃O₂S₂
Molecular Weight:327.387
Hs Code.:

Synonyms:(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

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Chemical Property of (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

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Technology Process of (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

There total 1 articles about (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 7170-77-6
2-amino-6-thiocyanatobenzothiazole

: 1885-14-9
phenyl chloroformate

: 1116743-49-7
(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 20h;
DOI:10.1021/acs.jmedchem.6b00280

Reference yield:

: 1116743-49-7
(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

: 1205125-03-6
phenyl [6-(imidazo[1,2-a]pyrimidin-3-ylsulphanyl)-1,3-benzothiazol-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 24 h / 20 °C

2: water; potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol / ethanol / 18 h / 20 °C / Reflux

3: potassium carbonate / water; dimethyl sulfoxide / 0.2 h / 190 °C / sealed tube; Microwave irradiation

4: pyridine / water / 48 h / 20 °C

With pyridine; potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol; water; potassium carbonate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1116743-49-7
(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate phenyl ester

: 1116743-46-4
1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / 20 °C

2: potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol / water; ethanol / 16 h / 20 °C / Inert atmosphere

3: triethylamine; sodium tetrahydroborate / N,N-dimethyl-formamide / 4 h / 20 - 95 °C

With sodium tetrahydroborate; potassium dihydrogenphosphate; 1,4-dithio-D,L-threitol; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00280