AZD 4818

Base Information

Chemical Name:AZD 4818
CAS No.:1003566-93-5
Molecular Formula:C₂₇H₃₂Cl₂N₂O₇
Molecular Weight:567.466
Hs Code.:
Mol file:1003566-93-5.mol

Synonyms:

Suppliers and Price of AZD 4818

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of AZD 4818

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of AZD 4818

There total 3 articles about AZD 4818 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1003566-93-5
AZD-4818

Guidance literature:: In 1-methyl-pyrrolidin-2-one; water; at 0 - 65 ℃; for 2.58h; Purification / work up;

Reference yield: 91.2%

: 1003567-17-6
2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

: 1003566-93-5
AZD-4818

Guidance literature:: 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester; With trifluoroacetic acid; In toluene; at 20 - 25 ℃; for 12h;

With ammonium acetate; In water; for 1 - 2h; Product distribution / selectivity;

Reference yield: 86.0%

: 1003567-28-9
2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid ethyl ester

: 1003566-93-5
AZD-4818

Guidance literature:: 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid ethyl ester; With sodium hydroxide; ethanol; water; at 40 - 45 ℃; for 3h;

With citric acid; In ethanol; water; for 1.83333h; Product distribution / selectivity;