2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

Base Information

Chemical Name:2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester
CAS No.:1003567-17-6
Molecular Formula:C₃₁H₄₀Cl₂N₂O₇
Molecular Weight:623.574
Hs Code.:

2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

Synonyms:2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

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Chemical Property of 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

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Technology Process of 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

There total 2 articles about 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

: 1003567-16-5
2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester

: 1003567-17-6
2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

Guidance literature:: 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester; In ethanol; water; at 20 - 50 ℃; for 9 - 10h;

Reference yield: 72.1%

: 1003567-16-5
2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester

: 1003567-30-3
5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt

: 1003567-17-6
2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

Guidance literature:: 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-(2-chloro-4-methylcarbamoyl-5-((S)-oxiran-2-ylmethoxy)phenoxy)-2-methylpropionic acid tert-butyl ester; In ethanol; at 20 - 50 ℃; for 8 - 9h;

Reference yield: 91.2%

: 1003567-17-6
2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester

: 1003566-93-5
AZD-4818

Guidance literature:: 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester; With trifluoroacetic acid; In toluene; at 20 - 25 ℃; for 12h;

With ammonium acetate; In water; for 1 - 2h; Product distribution / selectivity;