Irbinitinib

Base Information

Chemical Name:Irbinitinib
CAS No.:937263-43-9
Molecular Formula:C₂₆H₂₄N₈O₂
Molecular Weight:480.529
Hs Code.:
Mol file:937263-43-9.mol

Synonyms:Irbinitinib;

Suppliers and Price of Irbinitinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ARRY-380
25mg
$ 1760.00

DC Chemicals
Tucatinib(Irbinitinib,ARRY-380) >98%
10g
$ 2500.00

Crysdot
Irbinitinib 98+%
50mg
$ 243.00

Crysdot
Irbinitinib 98+%
100mg
$ 445.00

ChemScene
Tucatinib 99.82%
100mg
$ 450.00

ChemScene
Tucatinib 99.82%
50mg
$ 250.00

ChemScene
Tucatinib 99.82%
10mg
$ 90.00

ChemScene
Tucatinib 99.82%
500mg
$ 1650.00

Chemenu
N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine 98%
100mg
$ 982.00

AK Scientific
Tucatinib
25mg
$ 590.00

Total 71 raw suppliers

Chemical Property of Irbinitinib

Chemical Property:

PKA:6.61±0.70(Predicted)
PSA：110.85000
Density:1.41±0.1 g/cm3(Predicted)
LogP:4.67510

Purity/Quality:

99% ^*data from raw suppliers

ARRY-380 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Irbinitinib is also known as ARRY-380 or Tucatinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.
Uses N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine is a novel?diarylamine ErbB inhibitor.

Technology Process of Irbinitinib

There total 21 articles about Irbinitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1429755-58-7
1-(4-((4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea

: 937263-43-9
tucatinib

Guidance literature:: With p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran;

Reference yield: 78.2%

: 937263-71-3
4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline

: 4-hydroxy-6-(4,4-dimethyl-4,5-dihydrooxazol-2-amino)quinazoline

: 937263-43-9
tucatinib

Guidance literature:: 4-hydroxy-6-(4,4-dimethyl-4,5-dihydrooxazol-2-amino)quinazoline; With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In acetonitrile; at 20 ℃; for 0.5h; Green chemistry;

4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline; In acetonitrile; at 20 ℃; for 18h; Solvent; Reagent/catalyst; Temperature; Green chemistry;

Reference yield: 76.0%

: 4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate

: N⁴-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine

: 937263-43-9
tucatinib

Guidance literature:: 4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

N⁴-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine; In N,N-dimethyl-formamide; at 125 ℃; for 20h;
DOI:10.1055/s-0037-1610706