4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline

Base Information

• Chemical Name: 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline
• CAS No.: 937263-71-3
• Molecular Formula: C₁₃H₁₂N₄O
• Molecular Weight: 240.264
• Mol file: 937263-71-3.mol

Synonyms:4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline

Chemical Property of 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline

Chemical Property:

• Density: 1.34±0.1 g/cm3(Predicted)

Purity/Quality:

99.9% ^*data from raw suppliers

3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)benzenamine is a compound that may be used in the treatment of brain cancer.

Technology Process of 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline

There total 23 articles about 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a] pyridine (937263-44-0) → 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline (937263-71-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; at 45 ℃;

DOI:10.1158/1535-7163.MCT-19-0873

Reference yield: 73.0%

4-amino-2-methylphenol (2835-96-3) + 7-chloro-[1,2,4]triazolo[1,5-a]pyridine (1427452-48-9) → 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline (937263-71-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 16h; Solvent; Reagent/catalyst;

Reference yield:

(E)-N-hydroxy-N’-[4-(2-methyl-4-nitrophenoxy)pyridin-2-yl]methanimidamide → 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline (937263-71-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 40 ℃; for 16h;

upstream raw materials:

2-methyl-4-nitrophenol

4-chloro-2-nitropyridine

4-(2-methyl-4-nitrophenoxy)pyridin-2-amine

7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a] pyridine

Downstream raw materials:

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