MK 6096

Base Information

Chemical Name:MK 6096
CAS No.:1088991-73-4
Molecular Formula:C24H25FN4O2
Molecular Weight:420.487
Hs Code.:
Mol file:1088991-73-4.mol

Synonyms:Filorexant;;MK6096;MK 6096;

Suppliers and Price of MK 6096

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Filorexant
5mg
$ 140.00

DC Chemicals
Filorexant(mk-6096) >98%
100 mg
$ 500.00

DC Chemicals
Filorexant(mk-6096) >98%
1 g
$ 1800.00

DC Chemicals
Filorexant(mk-6096) >98%
250 mg
$ 900.00

Crysdot
MK-6096 98+%
50mg
$ 750.00

Crysdot
MK-6096 98+%
10mg
$ 290.00

Crysdot
MK-6096 98+%
5mg
$ 175.00

ChemScene
Filorexant 98.95%
5mg
$ 180.00

ChemScene
Filorexant 98.95%
10mg
$ 300.00

ChemScene
Filorexant 98.95%
100mg
$ 1176.00

Total 16 raw suppliers

Chemical Property of MK 6096

Chemical Property:

Boiling Point:540.2±50.0 °C(Predicted)
PKA:1.54±0.22(Predicted)
PSA：68.21000
Density:1.203±0.06 g/cm3(Predicted)
LogP:4.24370

Purity/Quality:

99%, ^*data from raw suppliers

Filorexant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 2.5 and 0.31 nM, respectively, for the recombinant human receptors). It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (Kb = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.
Uses Filorexant is a selective dual orexin receptor antagonist with potent sleep-promoting properties. It has advanced into phase II clinical trials for the treatment of insomnia.

Technology Process of MK 6096

There total 16 articles about MK 6096 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1088994-22-2
5-methyl-2-(pyrimidin-2-yl)benzoic acid

: C₁₂H₁₇FN₂O*(x)ClH

: 1088991-73-4
MK-6096

Guidance literature:: 5-methyl-2-(pyrimidin-2-yl)benzoic acid; With 2,6-dimethylpyridine; pivaloyl chloride; In N,N-dimethyl-formamide; at 5 - 10 ℃; for 0.5h; Inert atmosphere;

C₁₂H₁₇FN₂O*(x)ClH; With 2,6-dimethylpyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 10 - 25 ℃;

Reference yield: 88.0%

: 1088994-22-2
5-methyl-2-(pyrimidin-2-yl)benzoic acid

: C₁₂H₁₇FN₂O*ClH

: 1088991-73-4
MK-6096

Guidance literature:: With 2,6-dimethylpyridine; pivaloyl chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 15 - 25 ℃; Inert atmosphere;
DOI:10.1021/ol5028249

Reference yield:

: 1088994-22-2
5-methyl-2-(pyrimidin-2-yl)benzoic acid

: 1088993-93-4
5-fluoro-2-((3R,6R)-6-methyl-piperidin-3-ylmethoxy)pyridine

: 1088991-73-4
MK-6096

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 12 - 44 ℃; for 18h; Large scale;
DOI:10.1021/op3002678