5-methyl-2-(pyrimidin-2-yl)benzoic acid

Base Information

• Chemical Name: 5-methyl-2-(pyrimidin-2-yl)benzoic acid
• CAS No.: 1088994-22-2
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.224
• Hs Code.: 2933599090
• Mol file: 1088994-22-2.mol

Synonyms:5-Methyl-2-(pyrimidin-2-yl)benzoic acid;5-Methyl-2-pyrimidin-2-ylbenzoic acid;

Chemical Property of 5-methyl-2-(pyrimidin-2-yl)benzoic acid

Chemical Property:

• Appearance/Colour: white crystal powder
• Boiling Point: 315.514 °C at 760 mmHg
• PKA: 3.70±0.36(Predicted)
• Flash Point: 144.618 °C
• PSA: 63.08000
• Density: 1.26 g/cm³
• LogP: 2.15020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Methyl-2-(pyrimidin-2-yl)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-2-(pyrimidin-2-yl)benzoic acid

There total 11 articles about 5-methyl-2-(pyrimidin-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-methyl-2-(pyrimidin-2-yl)benzoic acid methyl ester (1088994-20-0) → 5-methyl-2-(pyrimidin-2-yl)benzoic acid (1088994-22-2)

Guidance literature:

With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 72 ℃; for 1.5h; Large scale;

DOI:10.1021/op3002678

Reference yield: 90.0%

5-methyl-2-pyrimidin-2-ylbenzonitrile (1373917-20-4) → 5-methyl-2-(pyrimidin-2-yl)benzoic acid (1088994-22-2)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; at 10 - 22 ℃; for 50h;

Reference yield: 90.0%

5-methyl-2-pyrimidin-2-ylbenzonitrile (1373917-20-4) → 5-methyl-2-(pyrimidin-2-yl)benzoic acid (1088994-22-2) + 4-methyl-2-(pyrimidin-2-yl)benzoic acid

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 10 - 22 ℃; for 50h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1021/ol5028249

upstream raw materials:

5-methyl-2-(pyrimidin-2-yl)benzoic acid methyl ester

2-bromo-5-methylbenzylnitrile

5-methyl-2-pyrimidin-2-ylbenzonitrile

2-iodoyl-5-methylbenzoic acid

Downstream raw materials:

MK-6096

(+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

(1R,4R,6R)-3-{[5-methyl-2-(2-pyrimidinyl)phenyl]carbonyl}-4-{2-[5-(trifluoromethyl)-2-pyridinyl]ethyl}-3-azabicyclo[4.1.0]heptane

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