P276

Base Information

Chemical Name:P276
CAS No.:920113-03-7
Molecular Formula:C21H20ClNO5.HCl
Molecular Weight:438.307
Hs Code.:

Synonyms:P-276-00;UNII-DRP53ZDY6H;4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-,hydrochloride (1:1);(+)-trans-2-(2-chlorophenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dihydroxy-chromen-4-one hydrochloride;

Suppliers and Price of P276

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
P276-00
1 mg
$ 650.00

Crysdot
P276-00(RivicilibHydrocloride) 95+%
10mg
$ 179.00

Crysdot
P276-00(RivicilibHydrocloride) 95+%
5mg
$ 107.00

Crysdot
P276-00(RivicilibHydrocloride) 95+%
25mg
$ 327.00

ChemScene
Riviciclibhydrochloride 98.33%
10mg
$ 300.00

ChemScene
Riviciclibhydrochloride 98.33%
5mg
$ 180.00

Total 14 raw suppliers

Chemical Property of P276

Chemical Property:

PSA：94.14000
LogP:4.04450

Purity/Quality:

99%, ^*data from raw suppliers

P276-00 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses P276-00 is a cyclin-dependent kinase (CDK) inhibitor. P276-00 has shown to be highly selective for cancer cells and has shown to produce potent inhibition of Cdk4-D1 activity. P276-00 also induces apoptosis in human promyelocytic leukemia (HL-60) cells.

Technology Process of P276

There total 13 articles about P276 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 920113-02-6
(+)-trans-2-(2-chloro-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one

: 920113-03-7
(+)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

: 920112-97-6
(-)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl]methanol

: 920113-03-7
(+)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 40 °C / Inert atmosphere

1.2: 25 - 70 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / -5 - 30 °C / Inert atmosphere

3.1: sodium hydride / 2-methyltetrahydrofuran / -5 - 0 °C / Inert atmosphere

3.2: 25 - 30 °C

4.1: pyridine hydrochloride; pyridine / 135 - 175 °C

5.1: hydrogenchloride / methanol; isopropyl alcohol / 25 - 50 °C

With pyridine; hydrogenchloride; pyridine hydrochloride; sodium hydride; acetic acid; triethylamine; In 2-methyltetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 118-91-2
ortho-chlorobenzoic acid

: 920113-03-7
(+)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]-4H-chromen-4-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / di-isopropyl ether / 5 - 30 °C

2.1: triethylamine / dichloromethane / -5 - 30 °C / Inert atmosphere

3.1: sodium hydride / 2-methyltetrahydrofuran / -5 - 0 °C / Inert atmosphere

3.2: 25 - 30 °C

4.1: pyridine hydrochloride; pyridine / 135 - 175 °C

5.1: hydrogenchloride / methanol; isopropyl alcohol / 25 - 50 °C

With pyridine; hydrogenchloride; oxalyl dichloride; pyridine hydrochloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; isopropyl alcohol;