2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel-

Base Information

Chemical Name:2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel-
CAS No.:117955-09-6
Molecular Formula:C15H23NO4
Molecular Weight:281.352
Hs Code.:

Synonyms:(+/-)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)-pyrrolidin-2-yl]-methanol;(+/-)-trans-[1-methyl-3-(2,4,6-trimethoxy-phenyl)-pyrrolidin-2-yl]-methanol;(+/-)-trans-(1-methyl-3-(2,4,6-trimethoxy-phenyl)pyrrolidin-2-yl)methanol;trans-2-hydroxymethyl-1-methyl-3-(2,4,6-trimethoxy)phenylpyrrolidine;[(2R,3S)-1-Methyl-3-(2,4,6-trimethoxy-phenyl)-pyrrolidin-2-yl]-methanol;

Suppliers and Price of 2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel-

Chemical Property:

PSA：51.16000
LogP:1.43030

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel-

There total 6 articles about 2-Pyrrolidinemethanol, 1-methyl-3-(2,4,6-trimethoxyphenyl)-, (2R,3S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (±)-trans-1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl acetic acid methyl ester

: 117955-09-6
(±)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl]methanol

Guidance literature:: With water; sodium hydroxide; In methanol; at 50 ℃; for 0.75h;

Reference yield:

: 113225-08-4,113225-12-0,113225-18-6,113225-19-7,117955-02-9,234771-34-7
(±)-trans-1-methyl-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol

: 117955-09-6
(±)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl]methanol

Guidance literature:: With sodium hydroxide; cesium acetate; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4020(01)90352-7

Reference yield:

: 113225-07-3
1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine

: 117955-09-6
(±)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 1.) boron trifluoride etherate, sodium borohydride; 2.) conc. HCl, 30 percent hydrogen peroxide / tetrahydrofuran; H₂O / 1.) 50 deg C, 1 h, up to 0 deg C; 2.) 50 deg C, 2 h

2: 0.83 g / 10percent NaOH, cesium acetate / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; cesium acetate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)90352-7