CEP-11981

Base Information

• Chemical Name: CEP-11981
• CAS No.: 856691-93-5
• Molecular Formula: C₂₈H₂₇N₇O
• Molecular Weight: 477.569
• Mol file: 856691-93-5.mol

Synonyms:UNII-J8AY0Z4CBP;

Chemical Property of CEP-11981

Chemical Property:

• PSA: 104.01000
• LogP: 4.07950

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CEP-11981

There total 8 articles about CEP-11981 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-amino-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (855260-38-7) + acetic acid (64-19-7,77671-22-8) + 2-bromopyrimidine (4595-60-2) → CEP-11981 (856691-93-5) + 2C2H4O2*C28H27N7O

Guidance literature:

11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-amino-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one; 2-bromopyrimidine; With triethylamine; In butan-1-ol; at 117 ℃; for 20h;

acetic acid; In butan-1-ol; at 75 ℃;

Reference yield:

2C2H4O2*C28H27N7O → CEP-11981 (856691-93-5)

Guidance literature:

In Isopropyl acetate; at 10 - 70 ℃; Industry scale;

Reference yield:

11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-amino-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (855260-38-7) → CEP-11981 (856691-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / butan-1-ol / 20 h / 117 °C / Industry scale

1.2: 0.25 h / 75 °C / Industry scale

2.1: Isopropyl acetate / 10 - 70 °C / Industry scale

With triethylamine; In Isopropyl acetate; butan-1-ol;

upstream raw materials:

11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-amino-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one

acetic acid

2-bromopyrimidine

5-cyano-2,10,11,12-tetrahydro-2-methyl-indazolo[5,4-a]carbazole-4-carboxylic acid ethyl ester

Refernces

• 1、 -. "METHOD FOR PURIFYING A FUSED PYRROLOCARBAZOLE DERIVATIVE". Page/Page column 21-22. . Retrieved 2011/12/04.