Chemical Property of Adarotene
Chemical Property:
- Melting Point:>240 °C
- Boiling Point:574.1±50.0 °C(Predicted)
- PKA:-95.54±0.10(Predicted)
- PSA：57.53000
- Density:1.257
- LogP:5.62480
- Solubility.:≥37.4 mg/mL in DMSO; insoluble in H2O; ≥10.97 mg/mL in EtOH with gentle warming and ultrasonic
- XLogP3:6.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:374.18819469
- Heavy Atom Count:28
- Complexity:574
- Purity/Quality:
-
97% *data from raw suppliers
Adarotene >98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)C=CC(=O)O)O
- Isomeric SMILES:C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)/C=C/C(=O)O)O
-
Uses
Adarotene has been found to have antitumor activity against different types of cancer, including acute myeloid leukemia, primary effusion lymphoma, prostate cancer and glioma. It may also be useful in treating acute lung injury through inflammation and ROS suppression via inactivating TLR4?/NF-?κB and p38?/ERK1?/2 signaling pathways.
