(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

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Chemical Name:(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester
CAS No.:1232886-08-6
Molecular Formula:C₄₁H₄₄O₃Si
Molecular Weight:612.884
Hs Code.:

Synonyms:(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

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Chemical Property of (E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

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Technology Process of (E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

There total 16 articles about (E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 496868-77-0
Adarotene

: 1232886-08-6
(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

Guidance literature:: With morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 496868-80-5
4-(4'-bromophenyl)-2-(adamantan-1-yl)phenol

: 1232886-08-6
(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / 1 h / 110 °C / Neat (no solvent)

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2.2: 5 h / 0 °C

3.1: dichloromethane / 20 °C

4.1: water / dimethyl sulfoxide / 24 h / 37 °C / pH 7.4 / aq. buffer

5.1: morpholine / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

With morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Heck reaction;
DOI:10.1016/j.bmc.2012.01.042

Reference yield:

: 1232884-73-9
(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyl ester

: 1232886-08-6
(E)-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid tert-butyldiphenylsilyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

1.2: 5 h / 0 °C

2.1: dichloromethane / 20 °C

3.1: water / dimethyl sulfoxide / 24 h / 37 °C / pH 7.4 / aq. buffer

4.1: morpholine / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

With morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.042