spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-

Base Information

Chemical Name:spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-
CAS No.:328232-95-7
Molecular Formula:C22H19FN4O3
Molecular Weight:406.416
Hs Code.:
UNII:HVE36P8422
ChEMBL ID:CHEMBL595573,CHEMBL4591460
Metabolomics Workbench ID:153206
Nikkaji Number:J2.228.680C
Wikidata:Q27280118

Synonyms:MK-0557;MK0557;spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-;trans-N-(1-(2-fluorophenyl)-3-pyrazolyl)-3-oxospiro(6-azaisobenzofuran-1(3H),1'-cyclohexane)-4'-carboxamide

Suppliers and Price of spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 17 raw suppliers

Chemical Property of spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:406.14411864
Heavy Atom Count:30
Complexity:669

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCC1C(=O)NC3=NN(C=C3)C4=CC=CC=C4F)C5=C(C=CN=C5)C(=O)O2
Recent ClinicalTrials:A 2-Year Study of an Investigational Drug in Obese Patients (0557-011)

Technology Process of spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-

There total 11 articles about spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 328233-23-4
trans-1'-oxospiro[1,3'-cyclohexane(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid

: 1-(2-fluorophenyl)-1H-pyrazol-3-amine hydrochloride

: 328232-95-7
MK-0557

Guidance literature:: trans-1'-oxospiro[1,3'-cyclohexane(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid; With thionyl chloride; In N,N-dimethyl acetamide; for 0.666667h; cooling;

1-(2-fluorophenyl)-1H-pyrazol-3-amine hydrochloride; With pyridine; In N,N-dimethyl acetamide; at 18 ℃; for 1h;
DOI:10.1021/jo0512709

Reference yield: 17.0%

: 685094-07-9
3-amino-1-(2-fluorophenyl)-1H-pyrazole

: 328233-23-4
trans-1'-oxospiro[1,3'-cyclohexane(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid

: 328232-95-7
MK-0557

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.bmc.2009.08.019

Reference yield:

: 1-(2-fluorophenyl)-1H-pyrazol-3-amine tosylate

: 328232-95-7
MK-0557

Guidance literature:: trans-1'-oxospiro[1,3'-cyclohexane(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid; With pyridine; thionyl chloride; In ISOPROPYLAMIDE; at -15 - -10 ℃;

1-(2-fluorophenyl)-1H-pyrazol-3-amine tosylate; In ISOPROPYLAMIDE; water; at -15 - 68 ℃;