tert-Butyl (3-aminocyclobutyl)carbamate

Base Information

• Chemical Name: tert-Butyl (3-aminocyclobutyl)carbamate
• CAS No.: 871014-19-6
• Molecular Formula: C9H18N2O2
• Molecular Weight: 186.254
• Hs Code.: 2924297099
• European Community (EC) Number: 823-439-7,823-847-5,847-695-4
• Mol file: 871014-19-6.mol

Synonyms:tert-Butyl (3-aminocyclobutyl)carbamate;1090904-48-5;1212395-34-0;871014-19-6;tert-butyl 3-aminocyclobutylcarbamate;tert-Butyl N-(3-aminocyclobutyl)carbamate;tert-Butyl (trans-3-aminocyclobutyl)carbamate;cis-tert-Butyl 3-aminocyclobutanecarbamate;CIS-TERT-BUTYL 3-AMINOCYCLOBUTYLCARBAMATE;trans-tert-butyl 3-aminocyclobutylcarbamate;TERT-BUTYL (CIS-3-AMINOCYCLOBUTYL)CARBAMATE;CIS TERT-BUTYL N-(3-AMINOCYCLOBUTYL)CARBAMATE;cis-tert-butyl N-(3-aminocyclobutyl)carbamate;CIS-N-BOC-1,3-DIAMINOCYCLOBUTANE;TRANS-N-BOC-1,3-DIAMINOCYCLOBUTANE;TRANS TERT-BUTYL N-(3-AMINOCYCLOBUTYL)CARBAMATE;tert-butyl N-[(1r,3r)-3-aminocyclobutyl]carbamate;MFCD09040641;MFCD11099896;tert-butyl ((1s,3s)-3-aminocyclobutyl)carbamate;tert-butyl N-[(1s,3s)-3-aminocyclobutyl]carbamate;MFCD12755997;TERT-BUTYL ((1R,3R)-3-AMINOCYCLOBUTYL)CARBAMATE;Tert-butyl(trans-3-aminocyclobutyl)carbamate;tert-Butyl ((cis)-3-Aminocyclobutyl)carbamate;tert-butyl (1r,3r)-3-aminocyclobutylcarbamate;tert-butyl ((trans)-3-aminocyclobutyl)carbamate;1-(Boc-amino)cyclobutan-3-amine;cis-1-(Boc-amino)cyclobutan-3-amine;trans-1-(Boc-amino)cyclobutan-3-amine;trans-N-Boc-1,3-cyclobutanediamine;N-[(1r,3r)-3-Aminocyclobutyl]carbamate;CS-WAA0308;SCHEMBL9970781;tert-butyl (cis-3-aminocy...;SCHEMBL12162998;SCHEMBL13018598;SCHEMBL14737457;OPDOEOOBYOABCJ-KNVOCYPGSA-N;OPDOEOOBYOABCJ-LJGSYFOKSA-N;BCP09860;cis-N1-Boc-cyclobutane-1,3-diamine;AKOS009108626;AKOS010366654;AKOS015949380;CS-W005385;GS-3750;PB14876;PB16119;SB10973;3-Amino-1-tert-butylcyclobutyl carbamate;cis-tert-Butyl3-aminocyclobutanecarbamate;Tert-butylN-(3-aminocyclobutyl)carbamate;AM803042;AM807308;AM807309;BS-13843;BS-13855;SY035913;SY042083;SY070837;tert-butyl 3-aminocyclobutylcarbamate-HCl;tert-butyl(cis-3-aminocyclobutyl)carbamate;CS-0045544;EN300-27068;EN300-53089;EN300-55580;tert-butyl (1s,3s)-3-aminocyclobutylcarbamate;tert-butyl((trans)-3-aminocyclobutyl)carbamate;trans-N-Boc-1,3-diaminocyclobutane, AldrichCPR;A862858;A891829;A895150;J-004465;J-524326;J-524339;cis-(3-amino-cyclobutyl)-carbamic acid tert-butyl ester;F8887-3890;Z237445442;Carbamic acid, N-(trans-3-aminocyclobutyl)-, 1,1-dimethylethyl ester;tert-butyl ((1r,3r)-3-aminocyclobutyl)carbamate

Chemical Property of tert-Butyl (3-aminocyclobutyl)carbamate

Chemical Property:

• Boiling Point: 102 °C(Press: 0.5 Torr)
• PKA: 12.32±0.40(Predicted)
• PSA: 64.35000
• Density: 1.06±0.1 g/cm3(Predicted)
• LogP: 2.09200
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 186.136827821
• Heavy Atom Count: 13
• Complexity: 192

Purity/Quality:

98%, ^*data from raw suppliers

transtert-ButylN-(3-Aminocyclobutyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1CC(C1)N

Technology Process of tert-Butyl (3-aminocyclobutyl)carbamate

There total 1 articles about tert-Butyl (3-aminocyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl (trans-3-azidocyclobutyl)carbamate (871014-18-5) → tert-butyl N-[(trans)-3-aminocyclobutyl]carbamate (871014-19-6,1090904-48-5)

Guidance literature:

With palladium 10% on activated carbon; ammonia; hydrogen; In methanol; for 2h;

DOI:10.1021/jo101271h

Reference yield: 95.0%

tert-butyl N-[(trans)-3-aminocyclobutyl]carbamate (871014-19-6,1090904-48-5) + 4-benzyl-1,4-diazepane-1-sulfonyl fluoride → tert-butyl ((1r,3r)-3-((4-benzyl-1,4-diazepane)-1-sulfonamido)cyclobutyl)carbamate

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; calcium(II) bis(trifluoromethanesulfonyl)imide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/acs.orglett.0c01397

Reference yield: 94.0%

tert-butyl N-[(trans)-3-aminocyclobutyl]carbamate (871014-19-6,1090904-48-5) + 4-nitro-benzoyl chloride (122-04-3) → tert-butyl {trans-3-[(4-nitrobenzoyl)amino]cyclobutyl}carbamate (1239589-55-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 1.5h; Reflux;

DOI:10.1021/jo101271h

upstream raw materials:

tert-butyl (trans-3-azidocyclobutyl)carbamate

Downstream raw materials:

tert-butyl {trans-3-[(4-nitrobenzoyl)amino]cyclobutyl}carbamate

Refernces