FMoc-(S)-2-aMino-3-hydroxy-3-Methylbutanoic acid

Base Information

• Chemical Name: FMoc-(S)-2-aMino-3-hydroxy-3-Methylbutanoic acid
• CAS No.: 1217603-41-2
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Hs Code.: 2924299090
• Mol file: 1217603-41-2.mol

Synonyms:L-Allothreonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-methyl-;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-3-methylbutanoic acid;FMOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID;

Chemical Property of FMoc-(S)-2-aMino-3-hydroxy-3-Methylbutanoic acid

Chemical Property:

• Boiling Point: 595.5±50.0 °C(Predicted)
• PKA: 3.50±0.10(Predicted)
• PSA: 95.86000
• Density: 1.300±0.06 g/cm3(Predicted)
• LogP: 3.14010
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMoc-(S)-2-aMino-3-hydroxy-3-Methylbutanoic acid

There total 7 articles about FMoc-(S)-2-aMino-3-hydroxy-3-Methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid hydrochloride + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-3-methylbutanoic acid (1217603-41-2)

Guidance literature:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid hydrochloride; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In 1,4-dioxane; water; at 20 ℃; for 3h;

Reference yield:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid hydrochloride + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-3-methylbutanoic acid (1217603-41-2)

Guidance literature:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid hydrochloride; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In 1,4-dioxane; water; at 20 ℃; for 3h;

Reference yield:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid (2280-27-5,5174-30-1) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-3-methylbutanoic acid (1217603-41-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.0c02640

upstream raw materials:

(S)-2-amino-3-hydroxy-3-methylbutanoic acid

(fluorenylmethoxy)carbonyl chloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

tert-butyl (4R)-4-(1-hydroxy-1-methylethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Refernces

• 1、 -. "COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE". Page/Page column 162. . Retrieved 2018/07/29.
• 2、 Inoue, Masayuki,Shinohara, Naoki,Tanabe, Shintaro,Takahashi, Tomoaki,Okura, Ken,Itoh, Hiroaki,Mizoguchi, Yuki,Iida, Maiko,Lee, Nayoung,Matsuoka, Shigeru. "Total synthesis of the large non-ribosomal peptide polytheonamide B". supporting information; scheme or table. p. 280 - 285. Retrieved 2010/09/03.