thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride

Base Information

Chemical Name:thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride
CAS No.:1247119-33-0
Molecular Formula:C23H28ClN3O2S
Molecular Weight:446.013
Hs Code.:
Mol file:1247119-33-0.mol

Synonyms:cobicistat intermediate; n-((1r,4r)-4-amino-5-phenyl-1-(phenylmethyl)pentyl)carbamic acid 5-thiazolylmethyl ester hydrochloride;

Suppliers and Price of thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Thiazol-5-ylmethyl((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamateHydrochloride
25mg
$ 365.00

Chemenu
thiazol-5-ylmethyl((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamatehydrochloride 97%
5g
$ 561.00

Chemenu
thiazol-5-ylmethyl((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamatehydrochloride 97%
10g
$ 916.00

Alichem
Thiazol-5-ylmethyl((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamatehydrochloride
5g
$ 654.00

AK Scientific
1,3-Thiazol-5-ylmethylN-[(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate;hydrochloride
1g
$ 2625.00

Total 33 raw suppliers

Chemical Property of thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride

Chemical Property:

PSA：108.97000
LogP:6.03750

Purity/Quality:

99%, ^*data from raw suppliers

Thiazol-5-ylmethyl((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamateHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.

Technology Process of thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride

There total 5 articles about thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 38585-74-9
thiazol-5-yl-methanol

: 75-44-5
phosgene

: (2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride

: 1247119-33-0
N-((1R,4R)-4-amino-5-phenyl-1-benzylpentyl)carbamic acid 5-thiazolylmethyl ester hydrochloride

Guidance literature:: thiazol-5-yl-methanol; phosgene; In dichloromethane; at 0 ℃; for 0.5h;

(2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride; With triethylamine; In dichloromethane; at 0 - 25 ℃; for 5h;

Reference yield: 83.0%

: (2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride

: 144163-97-3
((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

: 1247119-33-0
N-((1R,4R)-4-amino-5-phenyl-1-benzylpentyl)carbamic acid 5-thiazolylmethyl ester hydrochloride

Guidance literature:: (2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride; With potassium carbonate; In dichloromethane; water; at 20 ℃; for 1h; Industry scale;

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; Industry scale;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; Isopropyl acetate; Product distribution / selectivity; Industry scale;

Reference yield: 80.7%

: 38585-74-9
thiazol-5-yl-methanol

: 74124-79-1
di(succinimido) carbonate

: (2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride

: 1247119-33-0
N-((1R,4R)-4-amino-5-phenyl-1-benzylpentyl)carbamic acid 5-thiazolylmethyl ester hydrochloride

Guidance literature:: thiazol-5-yl-methanol; di(succinimido) carbonate; In acetonitrile; at 0 ℃; for 1h;

(2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride; With pyridine; In dichloromethane; at 0 - 25 ℃; for 9h;